Cytochalasin D

Cytochalasin D

SCHEMBL29375699

C=C1[C@@H](C)[C@H]2[C@H](Cc3ccccc3)NC(=O)[C@]23[C@H](OC(C)=O)/C=C\[C@@](C)(O)C(=O)[C@@H](C)C/C=C/[C@H]3[C@@H]1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR0B1 P51843 1/20 1.00
ADORA3 P0DMS8 1/20 0.79
CCR5 P51681 1/20 0.52
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
NPC1 O15118 2/20 0.46
LMNA P02545 1/20 0.46
SLC2A1 P11166 1/20 0.46
SLC2A2 P11168 1/20 0.46
SLC2A3 P11169 1/20 0.46
SLC2A4 P14672 1/20 0.46
MAPK1 P28482 1/20 0.46
RAB9A P51151 1/20 0.46
SLC2A9 Q9NRM0 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
HIF1A Q16665 1/20 0.46
PAX8 Q06710 1/20 0.46
ABCB1 P08183 8/20 0.33
CYP3A4 P08684 1/20 0.32
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Cytochalasin D SCHEMBL33528 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL16502284 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL33529 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL31734099 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL25847004 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
Cytochalasin D SCHEMBL12648577 1.00 NR0B1 (1.00) NR0B1ADORA3CCR5MEN1KMT2A
SCHEMBL29745878 0.93 NR0B1 (0.86) NR0B1ADORA3CCR5MEN1KMT2A
Zygosporin D SCHEMBL34014 0.89 NR0B1 (0.80) NR0B1ADORA3CCR5MEN1KMT2A
SCHEMBL22621306 0.88 NR0B1 (0.79) NR0B1ADORA3CCR5MEN1KMT2A
SCHEMBL33708 0.88 ADORA3 (1.00) NR0B1ADORA3CCR5MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 229 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3411059-B1 METHOD TO ENHANCE THE EFFICIENCY OF SYSTEMIC AAV GENE DELIVERY TO THE CENTRAL NERVOUS SYSTEM UNIV MASSACHUSETTS (US) 2026-05-06 EP claimed
EP-4058037-B1 FIBROBLAST-BASED THERAPY FOR TREATMENT AND PREVENTION OF STROKE SPINALCYTE LLC (US) 2026-01-28 EP claimed
EP-3350313-B1 DERIVATION OF LIVER ORGANOIDS FROM HUMAN PLURIPOTENT STEM CELLS AGENCY FOR SCIENCE TECH AND RESEARCH ASTARSTAR (SG) 2025-11-26 EP claimed
EP-3734274-B1 SYSTEM FOR MEASURING VISCOELASTIC PROPERTIES OF BLOOD C A CASYSO GMBH (CH) 2025-04-23 EP claimed
EP-4062962-B1 BLOOD TESTING SYSTEM AND METHOD C A CASYSO GMBH (CH) 2023-10-04 EP claimed
EP-3140650-B1 METHODOLOGIES AND REAGENTS FOR DETECTING FIBRINOLYSIS AND HYPERFIBRINOLYSIS HAEMONETICS CORP (US) 2022-07-20 EP claimed
US-20220125853-A1 MATERIALS AND METHODS FOR ENHANCING BONE CELL DIFFERENTIATION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2022-04-28 US claimed
EP-4308715-B1 HYBRID MOLECULE COMPRISING AN ANTIBODY FC FRAGMENT AND AT LEAST ONE FIBRIN-DERIVED CITRULLINATED PEPTIDE, AND USES THEREOF UNIV TOULOUSE 3 PAUL SABATIER (FR) 2026-05-13 EP disclosed
US-20260102503-A1 NANOCOMPOSITES FOR ENHANCED CELLULAR PAYLOAD DELIVERY UNIV TEXAS (US) 2026-04-16 US disclosed
US-20260092102-A1 COMPOSITIONS AND METHODS FOR USING BISPECIFIC ANTIBODIES TO BIND COMPLEMENT AND A TARGET ANTIGEN REGENERON PHARMACEUTICALS, INC. 2026-04-02 US disclosed
US-20260053804-A1 Compositions and Methods for the Restoration of Ciliary Function UNIV YALE (US) 2026-02-26 US disclosed
EP-4688821-A1 MICROGLIAL ENDOCYTIC RECEPTORS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASE CERIMMUNE THERAPEUTICS AB (SE) 2026-02-11 EP disclosed
US-12539271-B2 Nanoparticulate compositions EMPA Eidgenössische Materialprüfungs-und Forschungsanstalt (CH) 2026-02-03 US disclosed
CN-108780056-B Dielectric sensing for sample characterization 凯斯西储大学 2022-03-25 CN disclosed
WO-2022051592-A2 METHODS AND MATERIALS FOR TREATING CANCER MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) 2022-03-10 WO disclosed
CN-114113572-A Use of Piezo1 inhibitor for the manufacture of a medicament for the treatment or prevention of ectopic ossification 中山大学附属第一医院 2022-03-01 CN disclosed
US-11254944-B2 Agrobacterium derived cell penetrating peptides as nanocarriers INDIAN INSTITUTE OF TECHNOLOGY DELHI (IN) 2022-02-22 US disclosed
US-20220047719-A1 ENHANCING SUBCUTANEOUS INJECTION AND TARGET TISSUE ACCUMULATION OF NANOPARTICLES VIA CO-ADMINISTRATION WITH MACROPINOCYTOSIS INHIBITORY NANOPARTICLES (MINP) NORTHWESTERN UNIVERSITY 2022-02-17 US disclosed
EP-3947467-A1 METHODS OF DEPLETING DISEASE CAUSING AGENTS VIA ANTIBODY TARGETED PHAGOCYTOSIS Dren Bio, Inc. (US) 2022-02-09 EP disclosed
US-20220025331-A1 METHODS AND SYSTEMS FOR IMPROVING CELLS FOR USE IN THERAPY THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2022-01-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260092102-A1 COMPOSITIONS AND METHODS FOR USING BISPECIFIC ANTIBODIES TO BIND COMPLEMENT AND A TARGET ANTIGEN FCGR3B, FCGR2A, C1QBP NR0B1 1105/4885ADORA3 3157/4885CCR5 116/4885
US-12539271-B2 Nanoparticulate compositions CA7, CA1, CA13 NR0B1 3473/4885ADORA3 4713/4885CCR5 3501/4885
US-20260053804-A1 Compositions and Methods for the Restoration of Ciliary Function MTCL3, DYNLL2, CEP170 NR0B1 3871/4885ADORA3 3808/4885CCR5 4336/4885
US-20260102503-A1 NANOCOMPOSITES FOR ENHANCED CELLULAR PAYLOAD DELIVERY TNNT2, TELO2, MAPT NR0B1 3648/4885ADORA3 4468/4885CCR5 3996/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.