SCHEMBL31735743

SCHEMBL31735743

CC(=O)N1CCC(CCn2ccc3cc(Nc4cnn(C)c(=O)c4C)c(Cl)cc32)CC1

nearest known ligand 0.41

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 P04150 1/20 0.38
▸ JAK2 O60674 1/20 0.36
▸ JAK1 P23458 1/20 0.36
▸ TYK2 P29597 1/20 0.36
▸ JAK3 P52333 1/20 0.36
▸ TGFBR1 P36897 2/20 0.36
▸ IGF1R P08069 2/20 0.35
▸ CDK2 P24941 2/20 0.35
▸ BRD4 O60885 3/20 0.35
▸ BRD9 Q9H8M2 2/20 0.35
▸ PKM P14618 1/20 0.35
▸ LRRK2 Q5S007 1/20 0.34
▸ KCNH2 Q12809 1/20 0.34
▸ AXL P30530 1/20 0.34
▸ BPTF Q12830 1/20 0.34
▸ CREBBP Q92793 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31735869 0.90 PIK3CA (0.39) BRD4
SCHEMBL31735670 0.86 BRD9 (0.39) NR3C1BRD4BRD9BPTF
SCHEMBL31735634 0.86 NR3C1 (0.38) NR3C1JAK2JAK1TYK2JAK3
SCHEMBL31735567 0.84 NR3C1 (0.38) NR3C1JAK2JAK1TYK2JAK3
SCHEMBL31735635 0.82 BPTF (0.46) NR3C1BRD4BRD9BPTF
SCHEMBL31735640 0.77 BRD9 (0.41) BRD4BRD9BPTF
SCHEMBL31735699 0.76 PIK3CA (0.39) NR3C1BRD4
SCHEMBL31735878 0.75 BRD4 (0.42) BRD4BRD9BPTF
SCHEMBL31735652 0.74 BRD4 (0.40) JAK2JAK1TYK2JAK3IGF1R
SCHEMBL31735427 0.72 BRD9 (0.42) BRD4BRD9BPTF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025245484-A1 FOXN1 ACTIVATORS THYMOFOX INC. (US) 2025-11-27 — — WO disclosed
Send feedback