Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 5/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MTOR | P42345 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10801595 | 0.86 | SIGMAR1 (0.58) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| SCHEMBL3529740 | 0.84 | SIGMAR1 (0.66) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| SCHEMBL10867328 | 0.84 | SIGMAR1 (0.66) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| Hydrochloric Acid SCHEMBL5630513 | 0.83 | SIGMAR1 (0.62) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| Hydrochloric Acid SCHEMBL5630517 | 0.83 | SIGMAR1 (0.62) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| SCHEMBL11060007 | 0.83 | SIGMAR1 (0.55) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| Hydrochloric Acid SCHEMBL6350297 | 0.79 | SIGMAR1 (0.59) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| Hydrochloric Acid SCHEMBL6478894 | 0.79 | SIGMAR1 (0.59) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| SCHEMBL11527167 | 0.74 | LMNA (0.39) | OPRK1CYP3A4CYP2D6PMP22NFKB1 | |
| SCHEMBL7218504 | 0.74 | SIGMAR1 (1.00) | OPRK1CYP3A4CYP2D6PMP22NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652025-B2 | Remedies for sepsis | TORAY INDUSTRIES, INC. (JP) | 2010-01-26 | — | — | US | disclosed |
| US-7642274-B2 | Inhibitor of pain threshold decrease | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-01-05 | — | — | US | disclosed |
| US-20070117853-A1 | Inhibitor of pain threshold decrease | SANTEN PHARMACEUTICAL CO., LTD (JP) | 2007-05-24 | — | — | US | disclosed |
| EP-1642590-A1 | PAIN THRESHOLD FALL INHIBITOR | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2006-04-05 | — | — | EP | disclosed |
| US-20040147536-A1 | Remedies for sepsis | TORAY INDUSTRIES, INC. (JP) | 2004-07-29 | — | — | US | disclosed |
| EP-1402899-A1 | REMEDIES FOR SEPSIS | TORAY INDUSTRIES, INC. (JP) | 2004-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117853-A1 | Inhibitor of pain threshold decrease | OPRD1, OPRK1, OPRL1 | OPRK1 2/4885CYP3A4 1912/4885CYP2D6 3114/4885 |
| US-20040147536-A1 | Remedies for sepsis | OPRM1, OPRK1, OPRD1 | OPRK1 2/4885CYP3A4 123/4885CYP2D6 186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.