Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8626370 | 0.77 | CRBN (0.41) | HPGDNPSR1KMT2AHSD17B10ALOX15 | |
| SCHEMBL700746 | 0.77 | ALDH1A1 (0.44) | HPGDCASP1NPSR1MEN1KMT2A | |
| SCHEMBL7479018 | 0.73 | CA12 (0.31) | ALDH1A1L3MBTL1CA1CA2 | |
| SCHEMBL7840064 | 0.72 | CYP2D6 (0.38) | HPGDHTTCASP1NPSR1MEN1 | |
| SCHEMBL570014 | 0.71 | CHRNB4 (0.42) | KMT2AMAPK1ALDH1A1NPC1RAB9A | |
| SCHEMBL14854458 | 0.70 | MKNK1 (0.41) | — | |
| Oxirane SCHEMBL2207023 | 0.69 | ALDH1A1 (0.52) | HPGDHTTHSD17B10ALOX15ALDH1A1 | |
| SCHEMBL10583572 | 0.69 | HPGD (0.44) | HPGDHTTCASP1NPSR1MEN1 | |
| SCHEMBL10343777 | 0.68 | — | — | |
| SCHEMBL28574 | 0.65 | ALDH1A1 (0.67) | HPGDMEN1KMT2AHSD17B10ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411930-B1 | ISOXAZOLINE COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | CYTOKINE PHARMASCIENCES INC (US) | 2013-01-16 | — | — | EP | disclosed |
| US-7662843-B2 | Isoxazoline compounds having MIF antagonist activity | CYTOKINE PHARMASCIENCES, INC. (US) | 2010-02-16 | — | — | US | disclosed |
| EP-1411930-A4 | ISOXAZOLINE COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | CYTOKINE PHARMASCIENCES INC (US) | 2007-04-04 | — | — | EP | disclosed |
| US-20040204464-A1 | Isoxazoline compounds having MIF antagonist activity | CPSI STOCKHOLDER TRUST | 2004-10-14 | — | — | US | disclosed |
| EP-1411930-A2 | ISOXAZOLINE COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | Cytokine Pharmasciences, Inc. (US) | 2004-04-28 | — | — | EP | disclosed |
| WO-2002100332-A2 | ISOXAZOLINE COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | CYTOKINE PHARMASCIENCES, INC. (US) | 2002-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204464-A1 | Isoxazoline compounds having MIF antagonist activity | MIF, PGF, HLA-DRB1 | HPGD 2136/4885HTT 4757/4885CASP1 1523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.