SCHEMBL31755987

SCHEMBL31755987

COc1ccc(COc2cnc(Nc3ncc(-c4ccc(C(F)(F)F)cc4)o3)cc2C(=NO)NO)cc1

nearest known ligand 0.39

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 8/20 0.39
▸ FLT1 P17948 2/20 0.38
▸ FLT4 P35916 2/20 0.38
▸ KDR P35968 2/20 0.38
▸ SMPD1 P17405 1/20 0.37
▸ IMPDH2 P12268 1/20 0.37
▸ KIT P10721 1/20 0.36
▸ GSK3B P49841 1/20 0.35
▸ VCP P55072 1/20 0.35
▸ PPARD Q03181 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29696276 0.89 TRPV1 (0.42) TRPV1FLT1FLT4KDRSMPD1
SCHEMBL22925705 0.85 FLT1 (0.46) TRPV1FLT1FLT4KDRIMPDH2
SCHEMBL22925873 0.83 IMPDH2 (0.45) TRPV1FLT1FLT4KDRIMPDH2
SCHEMBL22926050 0.80 NPSR1 (0.39) TRPV1FLT1FLT4KDRIMPDH2
SCHEMBL28733678 0.80 NPSR1 (0.39) TRPV1FLT1FLT4KDRIMPDH2
SCHEMBL29620970 0.80 NPSR1 (0.39) TRPV1FLT1FLT4KDRIMPDH2
SCHEMBL31756267 0.80 TRPV1 (0.47) TRPV1FLT1KDRKITVCP
SCHEMBL28733676 0.79 TRPV1 (0.41) TRPV1FLT1FLT4KDRSMPD1
SCHEMBL22926080 0.78 IMPDH2 (0.43) TRPV1FLT1FLT4KDRIMPDH2
SCHEMBL29696304 0.78 IMPDH2 (0.43) TRPV1FLT1FLT4KDRIMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260001870-A1 INHIBITOR COMPOUNDS Cincera Therapeutics Pty Ltd (AU) 2026-01-01 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260001870-A1 INHIBITOR COMPOUNDS CES1, NCEH1, NR1H2 TRPV1 3641/4885FLT1 2182/4885FLT4 3558/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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