SCHEMBL31759009

SCHEMBL31759009

CC1(CO[Si](C)(C)C(C)(C)C)CCC(c2ccc(Cl)cc2)=C(COS(C)(=O)=O)C1

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.35
PTGS1 P23219 3/20 0.35
BCL2 P10415 3/20 0.35
BCL2L1 Q07817 1/20 0.33
SLC6A3 Q01959 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22325047 0.83 BCL2L1 (0.34) BCL2BCL2L1SLC6A3
SCHEMBL30857548 0.83 BCL2L1 (0.34) BCL2BCL2L1SLC6A3
SCHEMBL22325249 0.78 SLC6A3 (0.50) BCL2SLC6A3
SCHEMBL30834660 0.74 SLC6A3 (0.41) SLC6A3
SCHEMBL30857697 0.74 BCL2L1 (0.69) BCL2BCL2L1
SCHEMBL22325101 0.72 BCL2L1 (0.56) BCL2BCL2L1
SCHEMBL30857610 0.72 BCL2L1 (0.56) BCL2BCL2L1
SCHEMBL19867784 0.72 PTGS2 (0.50) PTGS2PTGS1BCL2BCL2L1
SCHEMBL31759015 0.70 BCL2L1 (0.48) BCL2BCL2L1
SCHEMBL22335527 0.68 SLC6A2 (0.40) SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260007685-A1 ANTI-APOPTOTIC BCL-2 FAMILY PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BERRYBIO HONG KONG LTD (CN) 2026-01-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260007685-A1 ANTI-APOPTOTIC BCL-2 FAMILY PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BCL2A1, BCL2, BCL2L1 PTGS2 2636/4885PTGS1 2095/4885BCL2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.