SCHEMBL317626

SCHEMBL317626

O=C(O)c1ccc(I)cc1N1C(=O)CCC1=O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA9 Q16790 1/20 0.42
GAA P10253 2/20 0.41
PTPRC P08575 1/20 0.38
PTPN2 P17706 1/20 0.38
PTPN1 P18031 1/20 0.38
PTPRA P18433 1/20 0.38
PTPRB P23467 1/20 0.38
PTPRE P23469 1/20 0.38
PTPN6 P29350 1/20 0.38
TP53 P04637 1/20 0.38
HPGD P15428 1/20 0.38
KMT2A Q03164 4/20 0.36
MAP2K1 Q02750 3/20 0.35
MAP2K2 P36507 2/20 0.35
MAPK1 P28482 1/20 0.35
MYC P01106 2/20 0.35
TPMT P51580 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6887707 0.81 CA12 (0.48) CA12CA1CA9GAAPTPN1
SCHEMBL31653832 0.80 KEAP1 (0.43) CA12CA1CA9GAATP53
SCHEMBL317703 0.80 KEAP1 (0.43) CA12CA1CA9GAATP53
SCHEMBL1834304 0.79 PKM (0.36) GAAPTPRCPTPN2PTPN1PTPRA
SCHEMBL1464604 0.79 CA12 (0.41) CA12CA1CA9GAATP53
SCHEMBL610788 0.79 CA12 (0.41) CA12CA1CA9GAAPTPN2
SCHEMBL10627311 0.78 MCL1 (0.42) CA12CA1CA9GAAPTPN2
SCHEMBL9596295 0.76 CA12 (0.39) CA12CA1CA9GAATP53
SCHEMBL4256629 0.76 GAA (0.41) CA12CA1CA9GAATP53
SCHEMBL9262225 0.75 GAA (0.55) CA12CA1CA9GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724457-A2 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING GLYPICAN-3 AND USES THEREOF Rayzebio, Inc. (US) 2026-04-15 EP disclosed
WO-2024254339-A9 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING GLYPICAN-3 AND USES THEREOF RAYZEBIO, INC. (US) 2025-10-16 WO disclosed
US-20250257148-A1 ATP-Dependent Agonists of Immune Cells Function as Anticancer Agents CROSSLINK THERAPEUTICS INC (US) 2025-08-14 US disclosed
EP-4594337-A2 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING EPHRIN TYPE-A RECEPTOR 2 AND USES THEREOF Rayzebio, Inc. (US) 2025-08-06 EP disclosed
WO-2025054553-A1 ATP-DEPENDENT AGONISTS OF IMMUNE CELLS FUNCTION AS ANTICANCER AGENTS CROSSLINK THERAPEUTICS INC. (US) 2025-03-13 WO disclosed
WO-2024254339-A2 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING GLYPICAN-3 AND USES THEREOF RAYZEBIO, INC. (US) 2024-12-12 WO disclosed
WO-2024073622-A2 RADIOPHARMACEUTICAL COMPOSITIONS TARGETING EPHRIN TYPE-A RECEPTOR 2 AND USES THEREOF RAYZEBIO, INC. (US) 2024-04-04 WO disclosed
US-11911488-B2 Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy THE JOHNS HOPKINS UNIVERSTY (US) 2024-02-27 US disclosed
US-20200360542-A1 SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY THE JOHNS HOPKINS UNIVERSTY 2020-11-19 US disclosed
US-10736974-B2 Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy THE JOHNS HOPKINS UNIVERSITY (US) 2020-08-11 US disclosed
US-20170333576-A1 NEW SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY THE JOHNS HOPKINS UNIVERSITY (US) 2017-11-23 US disclosed
US-8093405-B2 Formation of 18F and 19F fluoroarenes bearing reactive functionalities UNIVERSITY OF NEWCASTLE UPON TYNE (GB) 2012-01-10 US disclosed
EP-2310362-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES University Of Newcastle-Upon Tyne (GB) 2011-04-20 EP disclosed
WO-2009138763-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES UNIVERSITY OF NEWCASTLE UPON TYNE (GB) 2009-11-19 WO disclosed
US-20090286992-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES UNIVERSITY OF NEWCASTLE UPON TYNE (GB) 2009-11-19 US disclosed
EP-0920623-A4 BORON NEUTRON CAPTURE THERAPY USING PRE-TARGETING METHODS IMMUNOMEDICS INC (US) 2000-03-29 EP disclosed
EP-0920623-A1 BORON NEUTRON CAPTURE THERAPY USING PRE-TARGETING METHODS Immunomedics, Inc. (US) 1999-06-09 EP disclosed
US-5846741-A Boron neutron capture therapy using pre-targeting methods IMMUNOMEDICS, INC. (US) 1998-12-08 US disclosed
WO-1998004917-A1 BORON NEUTRON CAPTURE THERAPY USING PRE-TARGETING METHODS IMMUNOMEDICS INC. (US) 1998-02-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200360542-A1 SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY FOLH1, PSMA3, PSMA7 CA12 145/4885CA1 336/4885CA9 288/4885
US-20090286992-A1 FORMATION OF 18F AND 19F FLUOROARENES BEARING REACTIVE FUNCTIONALITIES RARB, RARG, RARA CA12 316/4885CA1 638/4885CA9 1392/4885
US-11911488-B2 Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy FOLH1, PSMA3, PSMA7 CA12 145/4885CA1 336/4885CA9 288/4885
US-20170333576-A1 NEW SCAFFOLDS AND MULTIFUNCTIONAL INTERMEDIATES FOR IMAGING PSMA AND CANCER THERAPY FOLH1, PSMA3, PSMA7 CA12 257/4885CA1 490/4885CA9 492/4885
US-10736974-B2 Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy FOLH1, PSMA3, PSMA7 CA12 145/4885CA1 336/4885CA9 288/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.