Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.46 |
| ▸ | HTR2C | P28335 | 4/20 | 0.46 |
| ▸ | HTR2B | P41595 | 2/20 | 0.46 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.38 |
| ▸ | TLR3 | O15455 | 1/20 | 0.38 |
| ▸ | TLR5 | O60602 | 1/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.38 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.38 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.38 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.38 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.38 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.38 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3806838 | 0.94 | HTR2A (0.47) | HTR2AHTR2CHTR2BHTR6HTR1D | |
| SCHEMBL16509893 | 0.90 | HTR2A (0.47) | HTR2AHTR2CHTR6HTR1DTRPM8 | |
| SCHEMBL3804876 | 0.90 | HTR2A (0.48) | HTR2AHTR2CHTR6HTR1DTRPM8 | |
| SCHEMBL1163144 | 0.88 | HTR2A (0.48) | HTR2AHTR6HTR1DTRPM8TAAR1 | |
| SCHEMBL1163485 | 0.85 | HTR2A (0.50) | HTR2AHTR2CHTR2BHTR6HTR1D | |
| SCHEMBL12595655 | 0.85 | HTR6 (0.46) | HTR2AHTR2CHTR2BHTR6TAAR1 | |
| SCHEMBL17147641 | 0.84 | HTR2A (0.49) | HTR2AHTR6HTR1DTRPM8TAAR1 | |
| SCHEMBL3177259 | 0.83 | HTR2A (0.47) | HTR2AHTR2CHTR2BHTR6HTR1D | |
| SCHEMBL1163387 | 0.83 | HTR2A (0.42) | HTR2AHTR6HTR1DTRPM8TAAR1 | |
| SCHEMBL23805220 | 0.82 | HTR2A (0.65) | HTR2AHTR2CHTR2BHTR6TLR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8071786-B2 | Indole compounds useful as serotonin selective agents | GALENEA CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071786-B2 | Indole compounds useful as serotonin selective agents | GALENEA CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-8071786-B2 | Indole compounds useful as serotonin selective agents | GALENEA CORP. (US) | 2011-12-06 | — | — | US | disclosed |
| US-20100137616-A1 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | SARD HOWARD P | 2010-06-03 | — | — | US | disclosed |
| US-7655691-B2 | Indole compounds useful as serotonin selective agents | ORGANIX, INC. | 2010-02-02 | — | — | US | disclosed |
| EP-1799640-A4 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | ORGANIX INC (US) | 2009-09-02 | — | — | EP | disclosed |
| EP-1799640-A2 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | Organix, Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20060100266-A1 | Indole compounds useful as serotonin selective agents | ORGANIX, INC. (US) | 2006-05-11 | — | — | US | disclosed |
| WO-2006047032-A2 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | ORGANIX, INC. (US) | 2006-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137616-A1 | INDOLE COMPOUNDS USEFUL AS SEROTONIN SELECTIVE AGENTS | TPH1, TPH2, AANAT | HTR2A 11/4885HTR2C 15/4885HTR2B 16/4885 |
| US-20060100266-A1 | Indole compounds useful as serotonin selective agents | TPH1, TPH2, AANAT | HTR2A 11/4885HTR2C 15/4885HTR2B 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.