Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.62 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL1617429 | 0.91 | TRPM8 (0.75) | TRPM8TRPA1LMNAMAPTEPHX1 | |
| Menthol SCHEMBL3378958 | 0.91 | TRPM8 (0.75) | TRPM8TRPA1LMNAMAPTEPHX1 | |
| Menthol SCHEMBL18787982 | 0.90 | TRPM8 (0.60) | TRPM8TRPA1LMNAMAPTEPHX1 | |
| Menthol SCHEMBL119538 | 0.87 | TRPM8 (0.64) | TRPM8TRPA1LMNAMAPTEPHX1 | |
| Menthol SCHEMBL2634088 | 0.85 | TRPM8 (0.66) | TRPM8TRPA1LMNAMAPTEPHX1 | |
| Menthol SCHEMBL2311281 | 0.82 | TRPM8 (0.78) | TRPM8TRPA1LMNAEPHX1KDM4E | |
| Menthol SCHEMBL28157641 | 0.82 | TRPM8 (0.84) | TRPM8TRPA1LMNAEPHX1KDM4E | |
| Levomenthol SCHEMBL22227514 | 0.82 | TRPM8 (0.84) | TRPM8TRPA1LMNAEPHX1KDM4E | |
| Menthol SCHEMBL4086460 | 0.82 | TRPM8 (0.84) | TRPM8TRPA1LMNAEPHX1KDM4E | |
| Menthol SCHEMBL28482985 | 0.81 | TRPM8 (0.60) | TRPM8TRPA1LMNAMAPTEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 384 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190037896-A1 | COOLING FORMULATIONS | WM. WRIGLEY JR. COMPANY (US) | 2019-02-07 | — | — | US | claimed |
| EP-3355710-A2 | COOLING FORMULATIONS | Wm. Wrigley Jr. Company (US) | 2018-08-08 | — | — | EP | claimed |
| US-7025999-B2 | Chewing gum having prolonged sensory benefits | WM. WRIGLEY JR. COMPANY (US) | 2006-04-11 | — | — | US | claimed |
| US-20050202118-A1 | Chewing gum products containing trigeminal stimulant and method of making the same | WM. WRIGLEY JR. COMPANY | 2005-09-15 | — | — | US | claimed |
| US-20030072842-A1 | Chewing gum having prolonged sensory benefits | WM. WRIGLEY JR. COMPANY | 2003-04-17 | — | — | US | claimed |
| WO-2002091849-A1 | A CHEWING GUM HAVING PROLONGED SENSORY BENEFITS | WM. WRIGLEY JR. COMPANY (US) | 2002-11-21 | — | — | WO | claimed |
| WO-2024102626-A1 | PRODUCTION OF NATURAL GUM BASE INGREDIENTS BY PLANT CELL FERMENTATION AND APPLICATION THEREOF IN CONFECTIONERY | WM. WRIGLEY JR. COMPANY (US) | 2024-05-16 | — | — | WO | disclosed |
| CN-117447748-B | Anti-aging ice-fire condom and preparation method thereof | 广州双一乳胶制品有限公司 | 2024-03-29 | — | — | CN | disclosed |
| US-11930830-B2 | System and method of forming multilayer confectionery | INTERCONTINENTAL GREAT BRANDS LLC (US) | 2024-03-19 | — | — | US | disclosed |
| CN-117447748-A | Anti-aging ice-fire condom and preparation method thereof | 广州双一乳胶制品有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-117440760-A | Chewing gum composition beneficial to skin | WM.雷格利 JR.公司 | 2024-01-23 | — | — | CN | disclosed |
| EP-4304372-A1 | CHEWING GUM COMPOSITIONS FOR SKIN BENEFITS | WM. Wrigley Jr. Company (US) | 2024-01-17 | — | — | EP | disclosed |
| US-20230329277-A1 | CANDY WITH VISUAL EFFECTS AND PRODUCTION METHODS THEREOF | BABIN KATHERINE DEJARNETTE (US) | 2023-10-19 | — | — | US | disclosed |
| WO-2006127605-A2 | CONFECTIONERY COMPOSITION INCLUDING AN ELASTOMERIC COMPONENT, A COOKED SACCHARIDE COMPONENT, AND A SWEETENER | CADBURY ADAMS USA LLC (US) | 2006-11-30 | — | — | WO | disclosed |
| US-20060263476-A1 | Center-filled chewing gum with barrier layer | CADBURY ADAMS USA, LLC. | 2006-11-23 | — | — | US | disclosed |
| US-20060263475-A1 | Center-filled chewing gum composition | CADBURY ADAMS USA, LLC. | 2006-11-23 | — | — | US | disclosed |
| US-7025999-B2 | Chewing gum having prolonged sensory benefits | WM. WRIGLEY JR. COMPANY (US) | 2006-04-11 | — | — | US | disclosed |
| US-20050202118-A1 | Chewing gum products containing trigeminal stimulant and method of making the same | WM. WRIGLEY JR. COMPANY | 2005-09-15 | — | — | US | disclosed |
| US-20030072842-A1 | Chewing gum having prolonged sensory benefits | WM. WRIGLEY JR. COMPANY | 2003-04-17 | — | — | US | disclosed |
| WO-2002091849-A1 | A CHEWING GUM HAVING PROLONGED SENSORY BENEFITS | WM. WRIGLEY JR. COMPANY (US) | 2002-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190037896-A1 | COOLING FORMULATIONS | TAS2R30, MGLL, TAS2R60 | TRPM8 83/4885TRPA1 305/4885LMNA 2069/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.