Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.75 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.75 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL2634088 | 0.94 | TRPM8 (0.66) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL2311281 | 0.91 | TRPM8 (0.78) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL318442 | 0.91 | TRPM8 (0.62) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL18787982 | 0.89 | TRPM8 (0.60) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL119538 | 0.89 | TRPM8 (0.64) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL28157641 | 0.87 | TRPM8 (0.84) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Levomenthol SCHEMBL22227514 | 0.87 | TRPM8 (0.84) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL3648445 | 0.87 | TRPM8 (0.84) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL4086460 | 0.87 | TRPM8 (0.84) | TRPM8TRPA1EPHX1LMNAKDM4E | |
| Menthol SCHEMBL27206346 | 0.87 | TRPM8 (0.91) | TRPM8TRPA1EPHX1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117924642-A | High-tear-resistance heat-resistant poly (siloxane-urethane) material and preparation method thereof | 常州大学 | 2024-04-26 | — | — | CN | claimed |
| CN-117813077-A | Composition and method for producing the same | 西姆莱斯股份公司 | 2024-04-02 | — | — | CN | claimed |
| CN-117615798-A | Composition for combating malodour | 西姆莱斯股份公司 | 2024-02-27 | — | — | CN | claimed |
| CN-113952388-A | Traditional Chinese medicine composition for oral bacteriostasis and preparation method thereof | 贵州医之星药业有限公司 | 2022-01-21 | — | — | CN | claimed |
| WO-2018116202-A1 | STABILIZED MOUTH FRESHENER STRIPS | AZISTA INDUSTRIES PVT LTD (IN) | 2018-06-28 | — | — | WO | claimed |
| CN-104188942-A | Transdermal absorption promoter, and external skin formulation thereof | TAKASAGO PERFUMERY CO LTD | 2014-12-10 | — | — | CN | claimed |
| US-20140219931-A1 | P-MENTHANE-3,8-DIOL ISOMER MIXTURE, COOLING SENSATION COMPOSITION COMPRISING THE SAME, AND PRODUCT COMPRISING THE COOLING SENSATION COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-08-07 | — | — | US | claimed |
| EP-2725900-A1 | ANTIMICROBIAL COMPOSITION | Takasago International Corporation (JP) | 2014-05-07 | — | — | EP | claimed |
| US-20130136704-A1 | P-MENTHANE-3,8-DIOL ISOMER MIXTURE, COMPOSITION COMPRISING THE SAME, AND PRODUCTS COMPRISING THE MIXTURE OR COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-05-30 | — | — | US | claimed |
| EP-2582357-A1 | TRANSDERMAL ABSORPTION PROMOTER, AND EXTERNAL SKIN FORMULATION THEREOF | Takasago International Corporation (JP) | 2013-04-24 | — | — | EP | claimed |
| CN-102939075-A | Percutaneous absorption promoter and external skin preparation thereof | TAKASAGO PERFUMERY CO LTD | 2013-02-20 | — | — | CN | claimed |
| US-20130005807-A1 | ANTIMICROBIAL COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-01-03 | — | — | US | claimed |
| WO-2013002421-A1 | ANTIMICROBIAL COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-01-03 | — | — | WO | claimed |
| EP-1761238-B1 | MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION COMPRISING THE SAME | TAKASAGO PERFUMERY CO LTD (JP) | 2012-09-05 | — | — | EP | claimed |
| WO-2011158964-A1 | TRANSDERMAL ABSORPTION PROMOTER, AND EXTERNAL SKIN FORMULATION THEREOF | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2011-12-22 | — | — | WO | claimed |
| US-7923585-B2 | Menthol derivative and cooling agent composition comprising the same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2011-04-12 | — | — | US | claimed |
| US-20070225378-A1 | Menthol Dearivative and Cooling Agent Composition Comprising the Same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-09-27 | — | — | US | claimed |
| EP-1615974-B1 | NON-TOXIC COATING COMPOSITION, METHODS OF USE THEREOF AND ARTICLES PROTECTED FROM ATTACHMENT OF BIOFOULING ORGANISMS | SYMRISE GMBH & CO KG (DE) | 2007-04-04 | — | — | EP | claimed |
| EP-1761238-A1 | MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION COMPRISING THE SAME | Takasago International Corporation (JP) | 2007-03-14 | — | — | EP | claimed |
| WO-2005115325-A1 | MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION COMPRISING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2005-12-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140219931-A1 | P-MENTHANE-3,8-DIOL ISOMER MIXTURE, COOLING SENSATION COMPOSITION COMPRISING THE SAME, AND PRODUCT COMPRISING THE COOLING SENSATION COMPOSITION | TRPM8, TAS2R8, TRPM7 | TRPM8 1/4885TRPA1 15/4885EPHX1 887/4885 |
| US-20070225378-A1 | Menthol Dearivative and Cooling Agent Composition Comprising the Same | TRPM7, TRPA1, TRPM2 | TRPM8 10/4885TRPA1 2/4885EPHX1 2023/4885 |
| US-20130136704-A1 | P-MENTHANE-3,8-DIOL ISOMER MIXTURE, COMPOSITION COMPRISING THE SAME, AND PRODUCTS COMPRISING THE MIXTURE OR COMPOSITION | TRPM8, NAPEPLD, TRPM4 | TRPM8 1/4885TRPA1 248/4885EPHX1 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.