Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.64 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.40 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL1617429 | 0.89 | TRPM8 (0.75) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL318442 | 0.87 | TRPM8 (0.62) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL6137747 | 0.86 | LMNA (0.58) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL2311281 | 0.84 | TRPM8 (0.78) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL2634088 | 0.83 | TRPM8 (0.66) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL18787982 | 0.82 | TRPM8 (0.60) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL3648445 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Levomenthol SCHEMBL22227514 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL28157641 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1LMNAKDM4EAPOBEC3A | |
| Menthol SCHEMBL4086460 | 0.80 | TRPM8 (0.84) | TRPM8TRPA1LMNAKDM4EAPOBEC3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 730 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220331344-A1 | ORAL FORMULATIONS OF PSYCHOTROPIC MACROFUNGUS BOTANICAL EXTRACTS WITH MOUTHFEEL EXPERIENCE ENHANCERS | CHICAGO ATLANTIC ADMIN, LLC | 2022-10-20 | — | — | US | claimed |
| US-20210212983-A1 | ORAL CANNABINOID DELIVERY FORMULATIONS WITH MOUTHFEEL EXPERIENCE ENHANCERS | CHICAGO ATLANTIC ADMIN, LLC | 2021-07-15 | — | — | US | claimed |
| CN-108135214-A | Cool taste preparation | WM.雷格利 JR.公司 | 2018-06-08 | — | — | CN | claimed |
| EP-1924148-B1 | CONFECTIONERY COMPOSITION INCLUDING AN ELASTOMERIC COMPONENT, A COOKED SACCHARIDE COMPONENT, AND A SENSATE | INTERCONTINENTAL GREAT BRANDS LLC (US) | 2016-07-20 | — | — | EP | claimed |
| EP-1534252-B1 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CARDAMOM OIL | WRIGLEY W M JUN CO (US) | 2010-06-30 | — | — | EP | claimed |
| EP-2001448-A2 | FLAVOR-ENHANCING COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE | Cadbury Adams USA LLC (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007089652-A2 | FLAVOR-ENHANCING COMPOSITIONS, METHODS OF MANUFACTURE, AND METHODS OF USE | CADBURY ADAMS USA LLC (US) | 2007-08-09 | — | — | WO | claimed |
| US-20070178123-A1 | FLAVOR-ENHANCING COMPOSITIONS, METHOD OF MANUFACTURE, AND METHODS OF USE | KRAFT FOODS GLOBAL BRANDS LLC | 2007-08-02 | — | — | US | claimed |
| WO-2006127738-A9 | COMPRESSIBLE CHEWING GUMS FOR DELIVERY OF ACTIVES | CADBURY ADAMS USA LLC (US) | 2007-05-31 | — | — | WO | claimed |
| WO-2006127740-A2 | INDICIA-BEARING PACKAGE FOR DELIVERY SYSTEMS FOR MANAGING RELEASE OF SWEETENERS, SENSATES, FUNCTIONAL INGREDIENTS, FOOD ACIDS AND FLAVORS IN A COMPRESSIBLE GUM SYSTEM | CADBURY ADAMS USA LLC (US) | 2006-11-30 | — | — | WO | claimed |
| US-20040253191-A1 | Breath Freshening and Oral Cleansing Product | WM. WRIGLEY JR. COMPANY | 2004-12-16 | — | — | US | claimed |
| US-20040253189-A1 | Breath Freshening and Oral Cleansing Product Using Geraniol | WM. WRIGLEY JR. COMPANY | 2004-12-16 | — | — | US | claimed |
| US-20040141927-A1 | Chewing gums, confections, mouthwashes, mouth sprays and edible thin film products | WM. WRIGLEY JR. COMPANY | 2004-07-22 | — | — | US | claimed |
| WO-2004045590-A1 | ORAL PRODUCTS CONTAINING NOVEL FLAVOR COMPOSITION | WM. WRIGLEY JR. COMPANY (US) | 2004-06-03 | — | — | WO | claimed |
| WO-2004019800-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019870-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING SALICYLALDEHYDE | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019922-A1 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CITRAL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019867-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CARDAMOM OIL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019802-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING CARVACROL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
| WO-2004019871-A2 | BREATH FRESHENING AND ORAL CLEANSING PRODUCT USING GERANIOL | WM. WRIGLEY JR. COMPANY (US) | 2004-03-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220331344-A1 | ORAL FORMULATIONS OF PSYCHOTROPIC MACROFUNGUS BOTANICAL EXTRACTS WITH MOUTHFEEL EXPERIENCE ENHANCERS | MB, MLEC, NISCH | TRPM8 1381/4885TRPA1 2103/4885LMNA 1978/4885 |
| US-20210212983-A1 | ORAL CANNABINOID DELIVERY FORMULATIONS WITH MOUTHFEEL EXPERIENCE ENHANCERS | CNR2, CNR1, CPNE4 | TRPM8 46/4885TRPA1 339/4885LMNA 2435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.