Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | F2R | P25116 | 1/20 | 0.43 |
| ▸ | CD44 | P16070 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28756376 | 0.83 | KDM4E (0.46) | KDM4EHIF1ATDP1ALDH1A1HPGD | |
| SCHEMBL14255774 | 0.83 | KDM4E (0.67) | KDM4EHIF1ATDP1ALDH1A1HPGD | |
| SCHEMBL27648478 | 0.82 | F2R (0.46) | KDM4EHIF1ATDP1F2RCYP2C9 | |
| SCHEMBL13647199 | 0.82 | ERCC5 (0.55) | F2RALDH1A1HPGDERCC5FEN1 | |
| SCHEMBL7547028 | 0.80 | CD44 (0.43) | KDM4EHIF1ATDP1CD44CYP2D6 | |
| SCHEMBL7547154 | 0.79 | CD44 (0.42) | KDM4EHIF1ATDP1CD44CYP2D6 | |
| SCHEMBL16168319 | 0.78 | KDM4E (0.44) | KDM4ETDP1F2RCYP2C9MYC | |
| SCHEMBL27608737 | 0.77 | ERCC5 (0.46) | KDM4EHIF1ATDP1CD44CYP2D6 | |
| SCHEMBL9116089 | 0.77 | F2R (0.42) | TDP1F2RCD44ALDH1A1HPGD | |
| SCHEMBL1260279 | 0.77 | ALDH1A1 (0.49) | KDM4EHIF1ATDP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7674936-B2 | Ortho-substituted aryl amides for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-03-09 | — | — | US | disclosed |
| EP-1423379-B1 | ORTHO-SUBSTITUTED ARYL AMIDES FOR CONTROLLING INVERTEBRATE PESTS | DU PONT (US) | 2008-05-28 | — | — | EP | disclosed |
| US-7288554-B2 | Ortho-substituted aryl amides for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-30 | — | — | US | disclosed |
| US-20070249832-A1 | Ortho-substituted aryl amides for controlling invertebrate pests | FMC CORPORATION | 2007-10-25 | — | — | US | disclosed |
| US-20040192731-A1 | Ortho-substituted aryl amides for controlling invertebrate pests | E. I. DU PONT DE NEMOURS AND COMPANY | 2004-09-30 | — | — | US | disclosed |
| US-20020183313-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-12-05 | — | — | US | disclosed |
| US-20020002163-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2002-01-03 | — | — | US | disclosed |
| US-6291452-B1 | CHOLECYSTOKININ ANTAGONISTS. | FUJISAWA PHARMACETICAL CO., LTD. (JP) | 2001-09-18 | — | — | US | disclosed |
| EP-0934282-A1 | 1,4-BENZODIAZEPINONES AND THEIR USES AS CCK ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998015535-A1 | 1,4-BENZODIAZEPINONES AND THEIR USES AS CCK ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-04-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040192731-A1 | Ortho-substituted aryl amides for controlling invertebrate pests | DDT, ACHE, CBR1 | KDM4E 1228/4885HIF1A 4503/4885TDP1 2975/4885 |
| US-20020002163-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | CCKAR, CCKBR, GABRA4 | KDM4E 1350/4885HIF1A 1240/4885TDP1 4401/4885 |
| US-20070249832-A1 | Ortho-substituted aryl amides for controlling invertebrate pests | NR2C2, GRK6, NR0B2 | KDM4E 2842/4885HIF1A 4420/4885TDP1 4686/4885 |
| US-20020183313-A1 | 1,4-benzodiazepinones and their uses as CCK antagonists | CCKAR, CCKBR, GABRA4 | KDM4E 1350/4885HIF1A 1240/4885TDP1 4401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.