Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | EDNRA | P25101 | 3/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30914450 | 1.00 | KMT2A (0.48) | KMT2AATMEDNRACA2ALDH1A1 | |
| SCHEMBL9787602 | 0.70 | ALDH1A1 (0.60) | ALDH1A1TSHRKDM4ELMNARECQL | |
| SCHEMBL9544951 | 0.69 | LMNA (0.69) | KMT2AALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL25531 | 0.69 | KMT2A (0.88) | KMT2AATMEDNRACA2F2 | |
| SCHEMBL29437927 | 0.69 | KMT2A (0.88) | KMT2AATMEDNRACA2F2 | |
| SCHEMBL5743956 | 0.66 | KMT2A (0.60) | KMT2AATMTSHRKDM4EHTT | |
| SCHEMBL5743967 | 0.66 | KMT2A (0.60) | KMT2AATMTSHRKDM4EHTT | |
| SCHEMBL31363195 | 0.66 | KMT2A (0.60) | KMT2AATMTSHRKDM4EHTT | |
| SCHEMBL23630459 | 0.65 | KMT2A (0.55) | KMT2AATMCA2F2PRSS1 | |
| SCHEMBL8366178 | 0.65 | KMT2A (0.55) | KMT2AATMCA2F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662361-B2 | Methods and compositions for modulating drug activity through telomere damage | AU JESSIE L-S | 2010-02-16 | — | — | US | disclosed |
| US-20060128651-A1 | Methods and compositions for modulating drug activity through telomere damage | AU JESSIE L | 2006-06-15 | — | — | US | disclosed |
| US-6995145-B1 | Methods and compositions for modulating drug activity through telomere damage | AU JESSIE L-S | 2006-02-07 | — | — | US | disclosed |
| WO-2000074667-A2 | COMPOSITIONS ACTIVE IN TELOMERE DAMAGE COMPRISING A TAXANE AND TELOMERASE INHIBITOR | AU JESSIE L S (US) | 2000-12-14 | — | — | WO | disclosed |