Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPID | Q08752 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19511852 | 0.92 | ALDH1A1 (0.51) | MMP9ALDH1A1MAPK1L3MBTL1SLC15A1 | |
| SCHEMBL19511851 | 0.92 | ALDH1A1 (0.51) | MMP9ALDH1A1MAPK1L3MBTL1SLC15A1 | |
| SCHEMBL1912567 | 0.83 | PPID (0.52) | PPIDALDH1A1PKMLTA4HMAPK1 | |
| SCHEMBL21555767 | 0.83 | ALDH1A1 (0.51) | MMP9ALDH1A1MAPK1L3MBTL1RAB9A | |
| SCHEMBL23011540 | 0.83 | PPID (0.46) | PPIDALDH1A1GPR142PKMMAPK1 | |
| SCHEMBL27692552 | 0.83 | MMP9 (0.44) | PPIDMMP9TACR1ALDH1A1MAPK1 | |
| SCHEMBL21284322 | 0.83 | PPID (0.46) | PPIDALDH1A1GPR142PKMMAPK1 | |
| SCHEMBL6435468 | 0.82 | MMP1 (0.47) | TACR1GPR142LTA4HPOLBRAB9A | |
| SCHEMBL17287421 | 0.82 | PPID (0.54) | PPIDTACR1ALDH1A1GPR142LTA4H | |
| SCHEMBL16079372 | 0.82 | PPID (0.54) | PPIDALDH1A1TSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1992613-B1 | PROCESS FOR PRODUCTION OF 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION | KYORIN SEIYAKU KK (JP) | 2013-01-30 | — | — | EP | disclosed |
| US-8084622-B2 | stereoselective asymmetric hydrogenation of 1-protected-4-alkoxycarbonyl-3-oxopyrrolidine, followed by ester hydrolysis, followed by amidation with cyclopropylamine; production of (3R,4S)-3-cyclopropylaminomethyl-4-fluoropyrrolidine useful as an intermediate to novel antibiotics | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2011-12-27 | — | — | US | disclosed |
| US-20100056805-A1 | Process for producing 3,4-disubstituted pyrrolidine derivative and production intermediate thereof | GOTOH TAKAYUKI | 2010-03-04 | — | — | US | disclosed |
| US-7667049-B2 | Process for producing 3,4-disubstituted pyrrolidine derivative and production intermediate thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2010-02-23 | — | — | US | disclosed |
| US-20090023935-A1 | Process for Producing 3,4-Disubstituted Pyrrolidine Derivative and Production Intermediate Thereof | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2009-01-22 | — | — | US | disclosed |
| EP-1992613-A1 | PROCESS FOR PRODUCTION OF 3,4-DISUBSTITUTED PYRROLIDINE DERIVATIVE AND INTERMEDIATE FOR THE PRODUCTION | Kyorin Pharmaceutical Co., Ltd. (JP) | 2008-11-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090023935-A1 | Process for Producing 3,4-Disubstituted Pyrrolidine Derivative and Production Intermediate Thereof | HPD, DHPS, HAAO | PPID 180/4885MMP9 4378/4885TACR1 3262/4885 |
| US-20100056805-A1 | Process for producing 3,4-disubstituted pyrrolidine derivative and production intermediate thereof | HPD, DHPS, HAAO | PPID 180/4885MMP9 4378/4885TACR1 3262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.