Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | PPIA | P62937 | 1/20 | 0.34 |
| ▸ | CCR2 | P41597 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | GHSR | Q92847 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318739 | 0.80 | CCR2 (0.35) | CCR2GRIN1GRIN2A | |
| SCHEMBL29547310 | 0.80 | CRBN (0.36) | CTSLPPIAGAAALDH1A1KMT2A | |
| SCHEMBL14019259 | 0.79 | GAA (0.35) | CCR2GAAP2RX7KMT2AMEN1 | |
| SCHEMBL7378722 | 0.77 | CTSL (0.39) | CTSLCTSK | |
| SCHEMBL319130 | 0.76 | PPIA (0.33) | CTSLPPIAGAAP2RX7NFKB1 | |
| SCHEMBL7376052 | 0.76 | CTSL (0.36) | CTSLPPIAGAANFKB1NFKB2 | |
| SCHEMBL318195 | 0.76 | CTSL (0.33) | CTSLGAAP2RX7KMT2AMEN1 | |
| SCHEMBL18592856 | 0.76 | GAA (0.33) | GAAP2RX7KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL7394465 | 0.73 | HPGDS (0.40) | CTSLGAAP2RX7KMT2AMEN1 | |
| SCHEMBL26670511 | 0.71 | POLB (0.40) | CTSLGAAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585447-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | Vertex Pharmaceuticals Incorporated (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2012006055-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OR PREVENTION OF FLAVIVIRUS INFECTIONS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-12 | — | — | WO | disclosed |