Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2591834 | 0.87 | GABRA2 (0.43) | MAPTMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL6883352 | 0.77 | POLB (0.38) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL10462143 | 0.76 | KDM4E (0.50) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL2648346 | 0.74 | ALDH1A1 (0.37) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL11216623 | 0.71 | CACNA1D (0.48) | MAPTMEN1KMT2ACACNA1DKDM4E | |
| SCHEMBL10346121 | 0.71 | KDM4E (0.58) | MAPTMEN1KMT2ACACNA1DKDM4E | |
| SCHEMBL2119667 | 0.69 | CACNA1D (0.48) | MAPTMEN1KMT2ACACNA1DKDM4E | |
| Ethyl Benzoate SCHEMBL27265201 | 0.65 | LMNA (0.68) | MAPTMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL2650255 | 0.65 | RAB9A (0.43) | MAPTMEN1KMT2AKDM4EGAA | |
| SCHEMBL10460378 | 0.65 | MAPT (0.50) | MAPTMEN1KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |