Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 4/20 | 0.34 |
| ▸ | SLC6A3 known ✓ | Q01959 | 4/20 | 0.34 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.30 |
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GPR3 | P46089 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28504288 | 0.82 | HTR2A (0.43) | HTR2ACA1CA2ADRA1ASLC6A2 | |
| SCHEMBL3198546 | 0.75 | HTR2A (0.37) | HTR2ACA1CA2ADRA1ASLC6A2 | |
| SCHEMBL27558719 | 0.74 | HTR2A (0.52) | HTR2ACA1CA2ADRA1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL3215554 | 0.73 | ALDH1A1 (0.35) | HTR2ASLC6A2SLC6A4SLC6A3KMT2A | |
| SCHEMBL10455243 | 0.72 | HTR2A (0.45) | HTR2ACA1CA2ADRA1ASLC6A2 | |
| SCHEMBL29175309 | 0.72 | HTR2A (0.45) | HTR2ACA1CA2GPR3CYP1A2 | |
| SCHEMBL28502205 | 0.71 | HTR2A (0.43) | HTR2ACA1CA2ADRA1ASLC6A2 | |
| Hydrochloric Acid SCHEMBL3212771 | 0.69 | HTR6 (0.33) | HTR2AADRA1ASLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL3261953 | 0.69 | HTR2A (0.35) | HTR2AGPR3DPP4 | |
| Hydrochloric Acid SCHEMBL3261208 | 0.68 | GPR3 (0.34) | HTR2AGPR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7671226-B2 | Transition metal complex, catalyst for olefin polymerization, and process for producing olefin polymer with the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-03-02 | — | — | US | disclosed |
| EP-1426379-B1 | TRANSITION METAL COMPLEX,CATALYST FOR OLEFIN POLYMERIZATION, AND PROCESS FOR PRODUCING OLEFIN POLYMER WITH THE SAME | SUMITOMO CHEMICAL CO (JP) | 2009-11-11 | — | — | EP | disclosed |
| US-7439379-B2 | Transition metal complex, catalyst for olefin polymerization, and process for producing olefin polymer with the same | SUMITOMO CHEMICAL CO., LTD. (JP) | 2008-10-21 | — | — | US | disclosed |