Sugi Predict

Sugi Predict / Compounds / SCHEMBL319867

SCHEMBL319867

SCHEMBL319867

O=c1cc[nH]c(=O)n1Cc1ccccc1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.53
▸ MEN1 O00255 4/20 0.53
▸ KMT2A Q03164 4/20 0.53
▸ L3MBTL1 Q9Y468 1/20 0.51
▸ SMN1; SMN2 Q16637 2/20 0.47
▸ KDM4E B2RXH2 1/20 0.46
▸ CYP1A2 P05177 3/20 0.45
▸ CYP2D6 P10635 3/20 0.45
▸ CYP2C19 P33261 3/20 0.45
▸ LMNA P02545 3/20 0.45
▸ CYP2C9 P11712 2/20 0.45
▸ TSHR P16473 2/20 0.45
▸ USP2 O75604 1/20 0.45
▸ CLK4 Q9HAZ1 1/20 0.45
▸ TNF P01375 1/20 0.44
▸ NOD2 Q9HC29 1/20 0.44
▸ NOD1 Q9Y239 1/20 0.44
▸ MAPT P10636 2/20 0.44
▸ CYP3A4 P08684 2/20 0.44
▸ POLB P06746 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5272693 0.79 ALDH1A1 (0.53) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL7750746 0.78 NOX4 (0.49) ALDH1A1KMT2ASMN1; SMN2MAPT
Ethylene SCHEMBL28028832 0.76 KDM4E (0.51) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL4372132 0.72 CCR8 (0.32) ALDH1A1KMT2ACYP3A4
SCHEMBL4348692 0.72 ADRA1D (0.37) MEN1KMT2ACYP1A2
SCHEMBL19784136 0.71 KMT2A (0.57) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2
Benzaldehyde SCHEMBL5801520 0.70 ALDH1A1 (0.44) ALDH1A1MEN1KMT2AL3MBTL1SMN1; SMN2
SCHEMBL30616060 0.69 ALDH1A1 (0.62) ALDH1A1MEN1KMT2AL3MBTL1CYP1A2
SCHEMBL29093705 0.69 ALDH1A1 (0.62) ALDH1A1MEN1KMT2AL3MBTL1CYP1A2
SCHEMBL10428820 0.69 ADRA1D (0.34) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2585068-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN Janssen Pharmaceutica, N.V. (BE) 2013-05-01 — — EP disclosed
EP-1866290-B1 PROKINETICIN 1 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA NV (BE) 2013-05-01 — — EP disclosed
US-8362247-B2 Prokineticin 1 receptor antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2013-01-29 — — US disclosed
US-20120245077-A1 PROKINETICIN 1 RECEPTOR MABUS JOHN R (US) 2012-09-27 — — US disclosed
US-8188081-B2 Methods of treating inflammation using prokineticin 1 receptor antagonists JANSSEN PHARMACEUTICA, NV (BE) 2012-05-29 — — US disclosed
US-20120129862-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS COATS STEVEN J (US) 2012-05-24 — — US disclosed
WO-2012006003-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN JANSSEN PHARMACEUTICA NV (BE) 2012-01-12 — — WO disclosed
US-20110319418-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN JANSSEN PHARMACEUTICA, NV (BE) 2011-12-29 — — US disclosed
US-7968710-B2 Gastrointestinal disorders;inflammatory bowel disorders; gastroesophageal reflux; constipation JANSSEN PHARMACEUTICA NV (BE) 2011-06-28 — — US disclosed
US-20110136811-A1 PROKINETICIN 1 RECEPTOR MABUS JOHN R 2011-06-09 — — US disclosed
US-7825117-B2 Methods of modulating intestine epithelial functions JANSSEN PHARMACEUTICA NV (BE) 2010-11-02 — — US disclosed
US-20080045535-A1 Prokineticin 2 receptor antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2008-02-21 — — US disclosed
EP-1869006-A1 PYRIMIDINDIONE DERIVATIVES AS PROKINETICIN 2 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-12-26 — — EP disclosed
EP-1868609-A2 PROKINETICIN 1 RECEPTOR JANSSEN PHARMACEUTICA N.V. (BE) 2007-12-26 — — EP disclosed
EP-1866290-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS Janssen Pharmaceutica, N.V. (BE) 2007-12-19 — — EP disclosed
US-20070021422-A1 Prokineticin 1 receptor JANSSEN PHARMACEUTICA NV (BE) 2007-01-25 — — US disclosed
US-20060235018-A1 Prokineticin 1 receptor antagonists JANSSEN PHARMACEUTICA N.V. (BE) 2006-10-19 — — US disclosed
WO-2006104715-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA, N.V. (BE) 2006-10-05 — — WO disclosed
WO-2006104713-A1 PYRIMIDINDIONE DERIVATIVES AS PROKINETICIN 2 RECEPTOR ANTAGONISTS JANSSEN PHARMACEUTICA, N.V. (BE) 2006-10-05 — — WO disclosed
WO-2006102112-A2 PROKINETICIN 1 RECEPTOR JANSSEN PHARMACEUTICA N.V. (BE) 2006-09-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080045535-A1 Prokineticin 2 receptor antagonists PROKR2, PROKR1, GIPR ALDH1A1 4503/4885MEN1 558/4885KMT2A 4161/4885
US-20060235018-A1 Prokineticin 1 receptor antagonists PROKR1, PROKR2, GIPR ALDH1A1 3674/4885MEN1 295/4885KMT2A 4664/4885
US-20110136811-A1 PROKINETICIN 1 RECEPTOR PROKR1, PROKR2, GIPR ALDH1A1 3305/4885MEN1 292/4885KMT2A 4529/4885
US-20120129862-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS PROKR1, PROKR2, GIPR ALDH1A1 3674/4885MEN1 295/4885KMT2A 4664/4885
US-20110319418-A1 PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN PROKR1, OPRL1, PROKR2 ALDH1A1 1729/4885MEN1 1815/4885KMT2A 4398/4885
US-20070021422-A1 Prokineticin 1 receptor PROKR1, PROKR2, GIPR ALDH1A1 3305/4885MEN1 292/4885KMT2A 4529/4885
US-20120245077-A1 PROKINETICIN 1 RECEPTOR PROKR1, PROKR2, GIPR ALDH1A1 3305/4885MEN1 292/4885KMT2A 4529/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.