Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14619249 | 1.00 | LOXL2 (0.47) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL14429871 | 1.00 | LOXL2 (0.47) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL22593409 | 0.81 | CYP2A6 (0.43) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL18884372 | 0.81 | CYP2A6 (0.43) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL6244539 | 0.81 | CYP2A6 (0.43) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL5464289 | 0.79 | CYP3A4 (0.44) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL5464291 | 0.79 | CYP3A4 (0.44) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL30707726 | 0.78 | ALDH1A1 (0.46) | ALDH1A1CA12CA2CA9CA14 | |
| SCHEMBL24468091 | 0.78 | CYP2A6 (0.45) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 | |
| SCHEMBL13557870 | 0.77 | CYP2A6 (0.52) | LOXL2ALDH1A1CYP2A6GRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4302764-A2 | C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE | Sage Therapeutics, Inc. (US) | 2024-01-10 | — | — | EP | disclosed |
| EP-3481845-B1 | C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE | SAGE THERAPEUTICS INC (US) | 2023-09-13 | — | — | EP | disclosed |
| EP-3481845-B1 | C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE | SAGE THERAPEUTICS INC (US) | 2023-09-13 | — | — | EP | disclosed |
| CN-116162121-A | C17, C20 and C21 substituted neuroactive steroids and methods of use thereof | 萨奇治疗股份有限公司 | 2023-05-26 | — | — | CN | disclosed |
| US-20230116347-A1 | C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE | SAGE THERAPEUTICS, INC. | 2023-04-13 | — | — | US | disclosed |
| CN-109689673-B | C17, C20 and C21 substituted neuroactive steroids and methods of use thereof | 萨奇治疗股份有限公司 | 2023-03-14 | — | — | CN | disclosed |
| US-11425910-B2 | Substituted oxadiazoles for combating phytopathogenic fungi | BASF SE (DE) | 2022-08-30 | — | — | US | disclosed |
| US-11396525-B2 | C17, C20, and C21 substituted neuroactive steroids and their methods of use | SAGE THERAPEUTICS, INC. (US) | 2022-07-26 | — | — | US | disclosed |
| US-11396525-B2 | C17, C20, and C21 substituted neuroactive steroids and their methods of use | SAGE THERAPEUTICS, INC. (US) | 2022-07-26 | — | — | US | disclosed |
| EP-3575286-B1 | PYRIDONE COMPOUND AND BACTERICIDE FOR AGRICULTURAL AND HORTICULTURAL USE, WHICH USES SAID COMPOUND AS ACTIVE INGREDIENT | MITSUI CHEMICALS AGRO INC (JP) | 2022-05-11 | — | — | EP | disclosed |
| CN-103097365-B | 5- (biphenyl-4-yl) -3-phenyl-1, 2, 4-oxadiazolyl derivatives as ligands on sphingosine-1-phosphate (S1P) receptors | MERCK SERONO S.A. (CH) | 2016-02-24 | — | — | CN | disclosed |
| US-9029405-B2 | 5-(biphenyl-4-yl)-3-phenyl-1,2,4-oxadiazolyl derivatives as ligands on the sphingosine 1-phosphate(SIP)receptors | MERCK SERONO S.A. (CH) | 2015-05-12 | — | — | US | disclosed |
| EP-2590956-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS | Merck Serono S.A. (CH) | 2013-05-15 | — | — | EP | disclosed |
| US-20130116289-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS | MERCK SERONO S.A. (CH) | 2013-05-09 | — | — | US | disclosed |
| CN-103097365-A | 5- (biphenyl-4-yl) -3-phenyl-1, 2, 4-oxadiazolyl derivatives as ligands on sphingosine-1-phosphate (S1P) receptors | MERCK SERONO SA | 2013-05-08 | — | — | CN | disclosed |
| WO-2012004287-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE (S1P) RECEPTORS | MERCK SERONO S.A. (CH) | 2012-01-12 | — | — | WO | disclosed |
| US-20050171132-A1 | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists | XIN ZHILI (US) | 2005-08-04 | — | — | US | disclosed |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | KOSOGOF CHRISTI (US) | 2005-08-04 | — | — | US | disclosed |
| WO-2005030734-A1 | DIAMINOPYRIMIDINE DERIVATIVES AS SELECTIVE GROWTH HORMONE SECRECTGOGUE RECEPTOR (GHS-R) ANTAGONISTS | ABBOTT LABORATORIES (US) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | ABBOTT LABORATORIES | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130116289-A1 | 5-(BIPHENYL-4-YL)-3-PHENYL-1,2,4-OXADIAZOLYL DERIVATIVES AS LIGANDS ON THE SPHINGOSINE 1-PHOSPHATE(SIP)RECEPTORS | S1PR1, S1PR5, S1PR2 | LOXL2 1005/4885ALDH1A1 2173/4885CYP2A6 3646/4885 |
| US-20230116347-A1 | C17, C20, AND C21 SUBSTITUTED NEUROACTIVE STEROIDS AND THEIR METHODS OF USE | CNR1, CNR2, GABRA1 | LOXL2 4016/4885ALDH1A1 348/4885CYP2A6 221/4885 |
| US-11396525-B2 | C17, C20, and C21 substituted neuroactive steroids and their methods of use | CNR1, CNR2, GABRA1 | LOXL2 4016/4885ALDH1A1 348/4885CYP2A6 221/4885 |
| US-20050171131-A1 | Diaminopyrimidine derivatives as growth hormone secrectgogue receptor (GHS-R) antagonists | GHSR, GIPR, GPR119 | LOXL2 4172/4885ALDH1A1 2435/4885CYP2A6 2406/4885 |
| US-20050171132-A1 | Diaminopyrimidine derivatives as selective growth hormone secrectgogue receptor (GHS-R) antagonists | GHSR, GIPR, GPR119 | LOXL2 4394/4885ALDH1A1 3084/4885CYP2A6 2698/4885 |
| US-11425910-B2 | Substituted oxadiazoles for combating phytopathogenic fungi | CYP51A1, DPM1, TH | LOXL2 1273/4885ALDH1A1 2017/4885CYP2A6 3560/4885 |
| US-20050070712-A1 | Pyrimidine derivatives as ghrelin receptor modulators | GPR119, GIPR, GCGR | LOXL2 4447/4885ALDH1A1 2333/4885CYP2A6 2837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.