SCHEMBL3200764

SCHEMBL3200764

COC(=O)c1ccc(C(F)(F)F)nc1NN

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.51
TUBB P07437 1/20 0.51
TUBA3C P0DPH7 1/20 0.51
TUBA1B P68363 1/20 0.51
TUBA4A P68366 1/20 0.51
TUBB4B P68371 1/20 0.51
TUBB3 Q13509 1/20 0.51
TUBB2A Q13885 1/20 0.51
TUBB8 Q3ZCM7 1/20 0.51
TUBA3E Q6PEY2 1/20 0.51
TUBA1A Q71U36 1/20 0.51
TUBA1C Q9BQE3 1/20 0.51
TUBB6 Q9BUF5 1/20 0.51
TUBB2B Q9BVA1 1/20 0.51
TUBB1 Q9H4B7 1/20 0.51
CFTR P13569 2/20 0.47
GAA P10253 5/20 0.41
P2RX7 Q99572 1/20 0.41
SDHB P21912 1/20 0.41
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2437507 0.86 TUBB4A (0.52) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29656731 0.84 TUBB4A (0.50) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29110222 0.84 TUBB4A (0.50) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL24761059 0.83 TAS2R14 (0.44) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL125591 0.81 TUBB4A (0.53) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL3878179 0.81 TUBB4A (0.56) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL29110319 0.80 MAPT (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL9264129 0.80 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL10667889 0.80 TUBB4A (0.54) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL4195184 0.80 LMNA (0.55) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3006444-B1 HETEROCYCLIC AMIDE COMPOUND NISSAN CHEMICAL IND LTD (JP) 2017-09-27 EP disclosed
US-9708314-B2 Heterocyclic amide compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2017-07-18 US disclosed
US-20160108037-A1 HETEROCYCLIC AMIDE COMPOUND NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2016-04-21 US disclosed
EP-3006444-A1 HETEROCYCLIC AMIDE COMPOUND Nissan Chemical Industries, Ltd. (JP) 2016-04-13 EP disclosed
US-20100035756-A1 TRIAZOLOPHYRIDINE DERIVATIVES AS HERBICIDES SYNGENTA LIMITED (GB) 2010-02-11 US disclosed
EP-2046788-A1 TRIAZOLOPYRIDINE DERIVATIVES AS HERBICIDES Syngeta Participations AG (CH) 2009-04-15 EP disclosed
WO-2008006540-A1 TRIAZOLOPYRIDINE DERIVATIVES AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2008-01-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100035756-A1 TRIAZOLOPHYRIDINE DERIVATIVES AS HERBICIDES DDT, CYP1A1, NAT1 TUBB4A 455/4885TUBB 180/4885TUBA3C 124/4885
US-20160108037-A1 HETEROCYCLIC AMIDE COMPOUND H1-0, H1-3, H1-2 TUBB4A 1183/4885TUBB 1471/4885TUBA3C 625/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.