SCHEMBL320330

SCHEMBL320330

ClCOc1cccc(OCCl)c1

nearest known ligand 0.45

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 2/20 0.45
TP53 P04637 2/20 0.45
CYP3A4 P08684 2/20 0.45
TSHR P16473 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
ALDH1A1 P00352 1/20 0.45
MAOB P27338 8/20 0.42
LMNA P02545 2/20 0.41
MAPK1 P28482 3/20 0.39
WDR5 P61964 1/20 0.39
APP P05067 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11833932 0.85 WDR5 (0.56) SMN1; SMN2MAOBLMNAMAPK1WDR5
SCHEMBL11613393 0.84 ACHE (0.56) MAOBLMNA
SCHEMBL13239972 0.84 BCHE (0.42) HIF1ATSHRSMN1; SMN2ALDH1A1MAOB
SCHEMBL3811486 0.84 CHRNB2 (0.55) CYP3A4TSHRALDH1A1LMNAAPP
SCHEMBL2431860 0.84 MAOB (0.60) ALDH1A1MAOBLMNAHTT
SCHEMBL1387264 0.84 TP53 (0.35) HIF1ATP53CYP3A4TSHRSMN1; SMN2
SCHEMBL10536278 0.84 CYP3A4 (0.64) TP53CYP3A4TSHRSMN1; SMN2ALDH1A1
Hydrochloric Acid SCHEMBL27573643 0.82 CYP3A4 (0.62) TP53CYP3A4TSHRSMN1; SMN2ALDH1A1
SCHEMBL3657427 0.82 LTA4H (0.51) MAOB
SCHEMBL14724872 0.80 TSHR (0.53) TSHRSMN1; SMN2MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105823841-A Method for detecting various chloroanisole in tobacco and tobacco products 上海烟草集团有限责任公司 2016-08-03 CN disclosed
EP-2590955-A1 SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS ABBVIE B.V. (NL) 2013-05-15 EP disclosed
WO-2012004378-A1 SPIRO-CYCLIC AMINE DERIVATIVES AS S1P MODULATORS ABBOTT HEALTHCARE PRODUCTS B.V. (NL) 2012-01-12 WO disclosed
EP-0603889-B1 Process for the preparation of lactic acid polyesters MITSUI CHEMICALS INC (JP) 2003-08-13 EP disclosed
US-6436961-B1 SUBSTANCE P RECEPTOR ANTAGONIST; 2-PHENYL-3-BENZYLAMINOPIPERIDINES PFIZER INC 2002-08-20 US disclosed
EP-0710684-B1 Preparation process of polyhydroxycarboxylic acid MITSUI CHEMICALS INC (JP) 2001-01-31 EP disclosed
US-5770683-A Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, INC. (JP) 1998-06-23 US disclosed
US-5646238-A Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, INC. (JP) 1997-07-08 US disclosed
EP-0710684-A2 Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-05-08 EP disclosed
US-5512653-A Lactic acid containing hydroxycarboxylic acid for the preparation of polhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, INC. (JP) 1996-04-30 US disclosed
US-5444143-A Preparation process of polyhydroxycarboxylic acid MITSUI TOATSU CHEMICALS, INC. (JP) 1995-08-22 US disclosed
US-5440008-A Condensation polymerization of hydroxycarboxylic acids in vertical reactor with ribbon stirrer, having flow pattern along walls in opposite direction to flow along axis of stirrer MITSUI TOATSU CHEMICALS, INC. (JP) 1995-08-08 US disclosed
EP-0603889-A2 Process for the preparation of lactic acid polyesters MITSUI TOATSU CHEMICALS, Inc. (JP) 1994-06-29 EP disclosed