Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 16/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 14/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3214852 | 0.83 | OPRK1 (0.79) | OPRK1OPRM1KCNH2EDNRBEDNRA | |
| SCHEMBL3200781 | 0.78 | OPRM1 (1.00) | OPRK1OPRM1KCNH2 | |
| Pf-04455242 SCHEMBL3212512 | 0.78 | OPRK1 (1.00) | OPRK1OPRM1KCNH2 | |
| Pf-04455242 SCHEMBL29664276 | 0.78 | OPRK1 (1.00) | OPRK1OPRM1KCNH2 | |
| Pf-04455242 SCHEMBL29484946 | 0.77 | OPRK1 (0.98) | OPRK1OPRM1KCNH2 | |
| SCHEMBL6904423 | 0.77 | OPRM1 (0.58) | OPRK1OPRM1ALDH1A1EDNRBEDNRA | |
| SCHEMBL3221376 | 0.75 | OPRM1 (0.54) | OPRK1OPRM1ALDH1A1 | |
| SCHEMBL3219520 | 0.73 | OPRK1 (0.77) | OPRK1OPRM1KCNH2 | |
| SCHEMBL3213443 | 0.73 | OPRK1 (0.77) | OPRK1OPRM1KCNH2 | |
| SCHEMBL3219508 | 0.73 | OPRK1 (0.77) | OPRK1OPRM1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | PFIZER INC | 2010-02-11 | — | — | US | claimed |
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | OPRK1, OPRD1, OPRL1 | OPRK1 1/4885OPRM1 4/4885KCNH2 281/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.