Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.54 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.45 |
| ▸ | FEN1 | P39748 | 5/20 | 0.45 |
| ▸ | DRD1 | P21728 | 3/20 | 0.44 |
| ▸ | NAT1 | P18440 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | FES | P07332 | 1/20 | 0.39 |
| ▸ | FER | P16591 | 1/20 | 0.39 |
| ▸ | MARK3 | P27448 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.39 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6904423 | 0.84 | OPRM1 (0.58) | OPRM1OPRK1ALOX5APFEN1ALDH1A1 | |
| SCHEMBL7803455 | 0.76 | DRD1 (0.46) | ALOX5APFEN1DRD1NAT1DRD2 | |
| SCHEMBL839417 | 0.76 | DRD1 (0.46) | DRD1NAT1DRD2DRD4DRD5 | |
| SCHEMBL6066480 | 0.75 | LMNA (0.41) | OPRM1OPRK1ALOX5APFEN1DRD1 | |
| SCHEMBL8511462 | 0.75 | LMNA (0.41) | OPRM1OPRK1ALOX5APFEN1DRD1 | |
| SCHEMBL6066470 | 0.75 | LMNA (0.41) | OPRM1OPRK1ALOX5APFEN1DRD1 | |
| SCHEMBL3204514 | 0.75 | OPRK1 (0.70) | OPRM1OPRK1ALDH1A1 | |
| SCHEMBL6066477 | 0.74 | NAT1 (0.42) | OPRM1OPRK1ALOX5APFEN1DRD1 | |
| SCHEMBL489577 | 0.73 | ALOX5AP (0.55) | ALOX5APFEN1NAT1 | |
| SCHEMBL1666926 | 0.72 | DRD1 (0.60) | DRD1NAT1DRD2DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | PFIZER INC | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035873-A1 | Diaryl Compounds and Uses Thereof | OPRK1, OPRD1, OPRL1 | OPRM1 4/4885OPRK1 1/4885ALOX5AP 2562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.