Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 3/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | LPO | P22079 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484647 | 1.00 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL3209999 | 0.82 | TSHR (0.41) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL13484645 | 0.82 | TSHR (0.41) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL17111315 | 0.73 | ALDH1A1 (0.38) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL31503973 | 0.69 | TSHR (0.50) | ALDH1A1LMNAMAPTKMT2AGAA | |
| SCHEMBL8436272 | 0.69 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPTKMT2AGAA | |
| SCHEMBL1289807 | 0.68 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL31042787 | 0.67 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL6129180 | 0.67 | ALDH1A1 (0.46) | ALDH1A1LMNAMAPTHPGDRAB9A | |
| SCHEMBL30896725 | 0.66 | POLB (0.35) | ALDH1A1LMNAMAPTHPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | claimed |
| EP-2029536-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-03-04 | — | — | EP | claimed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | claimed |
| EP-2029536-B1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | ESTEVE LABOR DR (ES) | 2013-08-28 | — | — | EP | disclosed |
| US-8299113-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-10-30 | — | — | US | disclosed |
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | disclosed |
| EP-2029536-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | CYP11B2, CYP11B1, SDHA | ALDH1A1 586/4885LMNA 2795/4885MAPT 1219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.