Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13484645 | 1.00 | TSHR (0.41) | TSHRDPP4DPP8DPP9CYP2C19 | |
| SCHEMBL3205149 | 0.82 | ALDH1A1 (0.45) | TSHRDPP4DPP8DPP9CYP2C19 | |
| SCHEMBL13484647 | 0.82 | ALDH1A1 (0.45) | TSHRDPP4DPP8DPP9CYP2C19 | |
| SCHEMBL6129180 | 0.81 | ALDH1A1 (0.46) | TSHRCYP2C19CYP3A4ALDH1A1MAPT | |
| SCHEMBL4089646 | 0.78 | ALDH1A1 (0.43) | TSHRCYP2C19CYP3A4ALDH1A1MAPT | |
| SCHEMBL28201107 | 0.78 | ALDH1A1 (0.43) | TSHRCYP2C19CYP3A4ALDH1A1MAPT | |
| SCHEMBL3898658 | 0.78 | ALDH1A1 (0.43) | TSHRCYP2C19CYP3A4ALDH1A1MAPT | |
| SCHEMBL3353702 | 0.77 | ALDH1A1 (0.40) | TSHRCYP2C19CYP3A4ALDH1A1MAPT | |
| SCHEMBL2961890 | 0.76 | ALDH1A1 (0.42) | CYP2C19CYP3A4ALDH1A1MAPTLMNA | |
| SCHEMBL13472662 | 0.74 | ALDH1A1 (0.46) | TSHRCYP2C19CYP3A4ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | claimed |
| EP-2029536-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-03-04 | — | — | EP | claimed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | claimed |
| EP-2029536-B1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | ESTEVE LABOR DR (ES) | 2013-08-28 | — | — | EP | disclosed |
| US-8299113-B2 | Bicyclic tetrahydropyrrole compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-10-30 | — | — | US | disclosed |
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2010-02-04 | — | — | US | disclosed |
| EP-2029536-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007128458-A1 | BICYCLIC TETRAHYDROPYRROLE COMPOUNDS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029738-A1 | Bicyclic Tetrahydropyrrole Compounds | CYP11B2, CYP11B1, SDHA | TSHR 1821/4885DPP4 2838/4885DPP8 3046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.