Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1174688 | 0.80 | TPMT (0.50) | RAF1CYP3A4MAPTSMN1; SMN2TSHR | |
| SCHEMBL16769484 | 0.80 | CA5A (0.44) | CYP3A4MAPTERN1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18471225 | 0.77 | SMN1; SMN2 (0.49) | PARP1CYP3A4MAPTBRD4BRD9 | |
| SCHEMBL10831613 | 0.77 | PARP1 (0.46) | PARP1CYP3A4MAPTBRD4BRD9 | |
| SCHEMBL13316834 | 0.76 | RAF1 (0.38) | RAF1PKMYT1PARP1BRD4BRD9 | |
| SCHEMBL15299942 | 0.75 | ALDH1A1 (0.50) | CYP3A4MAPTERN1TSHRALDH1A1 | |
| SCHEMBL3220166 | 0.75 | CA1 (0.48) | PARP1CYP3A4MAPTBRD4SMN1; SMN2 | |
| SCHEMBL1397262 | 0.75 | POLB (0.50) | PARP1CYP3A4MAPTBRD4BRD9 | |
| SCHEMBL1004660 | 0.75 | PARP1 (0.50) | PARP1CYP3A4MAPTBRD4BRD9 | |
| SCHEMBL13488142 | 0.74 | RAF1 (0.34) | RAF1PKMYT1PARP1BRD4BRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108026032-B | Method for producing optically active 4-carbamoyl-2, 6-dimethylphenylalanine derivative | 株式会社钟化 | 2020-09-29 | — | — | CN | claimed |
| CN-108026032-A | The manufacture method of optical activity 4- carbamoyl -2,6- 3,5-dimethylphenyl alanine derivatives | 株式会社钟化 | 2018-05-11 | — | — | CN | claimed |
| CN-108026032-B | Method for producing optically active 4-carbamoyl-2, 6-dimethylphenylalanine derivative | 株式会社钟化 | 2020-09-29 | — | — | CN | disclosed |
| CN-108026032-A | The manufacture method of optical activity 4- carbamoyl -2,6- 3,5-dimethylphenyl alanine derivatives | 株式会社钟化 | 2018-05-11 | — | — | CN | disclosed |
| EP-1858850-B1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-21 | — | — | EP | disclosed |
| EP-1858850-B1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-21 | — | — | EP | disclosed |
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | CAI CHAOZHONG | 2010-06-17 | — | — | US | disclosed |
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | CAI CHAOZHONG | 2010-06-17 | — | — | US | disclosed |
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | CAI CHAOZHONG | 2010-06-17 | — | — | US | disclosed |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | CAI CHAOZHONG | 2010-02-11 | — | — | US | disclosed |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | CAI CHAOZHONG | 2010-02-11 | — | — | US | disclosed |
| US-7629488-B2 | 2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid; treatment and prevention of pain and gastrointestinal disorders; cost efficiency, industrial scale production | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7629488-B2 | 2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid; treatment and prevention of pain and gastrointestinal disorders; cost efficiency, industrial scale production | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| US-7629488-B2 | 2-tert-Butoxycarbonylamino-3-(4-carbamoyl-2,6-dimethylphenyl)propionic acid; treatment and prevention of pain and gastrointestinal disorders; cost efficiency, industrial scale production | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-12-08 | — | — | US | disclosed |
| EP-1863764-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1858850-A2 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-11-28 | — | — | EP | disclosed |
| WO-2006099060-A2 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-21 | — | — | WO | disclosed |
| WO-2006098982-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2006-09-21 | — | — | WO | disclosed |
| US-20060211863-A1 | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
| US-20060211861-A1 | Process for the preparation of opioid modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152460-A1 | PROCESS FOR THE PREPARATION OF OPIOID MODULATORS | OPRM1, OPRK1, OPRL1 | RAF1 4171/4885PKMYT1 1325/4885PARP1 4664/4885 |
| US-20060211861-A1 | Process for the preparation of opioid modulators | OPRM1, OPRK1, OPRL1 | RAF1 4171/4885PKMYT1 1325/4885PARP1 4664/4885 |
| US-20100036132-A1 | PROCESS FOR THE PREPARATION OF OPIOD MODULATORS | OPRM1, OPRL1, OPRK1 | RAF1 4286/4885PKMYT1 1664/4885PARP1 4710/4885 |
| US-20060211863-A1 | Process for the preparation of opioid modulators | OPRM1, OPRK1, OPRL1 | RAF1 4171/4885PKMYT1 1325/4885PARP1 4664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.