Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | LTK | P29376 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207131 | 0.82 | RORC (0.43) | PTPN5MAOBAKR1C3AKR1C2ADORA1 | |
| SCHEMBL2430766 | 0.82 | NT5E (0.41) | PDK2MAP4K4PIM1PRKACAGSK3B | |
| SCHEMBL3678971 | 0.81 | ENPP1 (0.40) | ENPP1PDK2ARPTPN5ADRA2A | |
| SCHEMBL5198909 | 0.81 | PDK2 (0.40) | PDK2MAOBADORA1 | |
| SCHEMBL4279210 | 0.81 | HSD17B1 (0.41) | ARMAP4K4PDGFRBPIM1FGFR1 | |
| SCHEMBL455371 | 0.79 | ALDH1A1 (0.40) | ENPP1 | |
| SCHEMBL3537988 | 0.78 | ACHE (0.41) | ENPP1PDK2CNR2CNR1CHEK1 | |
| SCHEMBL8074571 | 0.77 | PTPN5 (0.34) | PTPN5 | |
| SCHEMBL7007684 | 0.76 | HTR7 (0.38) | — | |
| SCHEMBL2428521 | 0.75 | HSD17B1 (0.34) | PDK2ARMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683082-B2 | 3-(5-p-tolyl-[1,2,4]oxadiazol-3-yl)-benzoic acid; translation of mRNA is allowed to continue past a nonsense mutation point, resulting in full length protein; genetic disorders; testing whether a compound increases activity of a protein encoded by an mRNA that contains a premature stop codon | PTC THERAPEUTICS, INC. (US) | 2010-03-23 | — | — | US | disclosed |