Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3201922 | 0.88 | HSD11B1 (0.69) | HSD11B1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3205817 | 0.86 | HSD11B1 (0.76) | HSD11B1ALDH1A1LMNATSHRMAPK1 | |
| SCHEMBL3221923 | 0.83 | ALDH1A1 (0.52) | HSD11B1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3215041 | 0.82 | PKM (0.65) | HSD11B1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL3226058 | 0.81 | HSD11B1 (0.77) | HSD11B1LMNAHTTSMN1; SMN2TSHR | |
| SCHEMBL3213328 | 0.76 | HSD11B1 (0.80) | HSD11B1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL4948991 | 0.76 | PKM (0.59) | HSD11B1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5309988 | 0.74 | HTT (0.73) | HSD11B1ALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL5257034 | 0.74 | HTT (0.67) | HSD11B1ALDH1A1LMNAHTTTSHR | |
| SCHEMBL5251544 | 0.74 | LMNA (0.78) | HSD11B1LMNAHTTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | HSD11B1 1/4885ALDH1A1 116/4885LMNA 3748/4885 |
| US-20070219198-A1 | 11-Beta HSD 1 inhibitors | HSD11B1, HSD11B2, HSD3B1 | HSD11B1 1/4885ALDH1A1 123/4885LMNA 3681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.