Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 5/20 | 0.63 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.61 |
| ▸ | PPARG | P37231 | 7/20 | 0.61 |
| ▸ | PPARD | Q03181 | 7/20 | 0.61 |
| ▸ | PPARA | Q07869 | 7/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.61 |
| ▸ | TSHR | P16473 | 4/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | TLR2 | O60603 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | FABP4 | P15090 | 2/20 | 0.61 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.61 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | ESR1 | P03372 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453928 | 0.98 | GPR84 (0.64) | BBOX1GPR84PPARGPPARDPPARA | |
| SCHEMBL5455915 | 0.98 | GPR84 (0.64) | BBOX1GPR84PPARGPPARDPPARA | |
| SCHEMBL5453095 | 0.98 | GPR84 (0.64) | BBOX1GPR84PPARGPPARDPPARA | |
| SCHEMBL5459522 | 0.98 | GPR84 (0.64) | BBOX1GPR84PPARGPPARDPPARA | |
| SCHEMBL5452909 | 0.98 | GPR84 (0.64) | BBOX1GPR84PPARGPPARDPPARA | |
| SCHEMBL5456917 | 0.98 | GPR84 (0.64) | BBOX1GPR84PPARGPPARDPPARA | |
| Stearic Acid SCHEMBL27477635 | 0.96 | GPR84 (0.68) | BBOX1GPR84PPARGPPARDPPARA | |
| Hydrochloric Acid SCHEMBL3212988 | 0.96 | GPR84 (0.68) | BBOX1GPR84PPARGPPARDPPARA | |
| SCHEMBL8332393 | 0.94 | GPR84 (0.71) | GPR84PPARGPPARDPPARAHDAC11 | |
| SCHEMBL5463837 | 0.94 | GPR84 (0.71) | GPR84PPARGPPARDPPARAHDAC11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160282-A1 | NOVEL DIPHENYLAZETIDINONES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS AND THEIR USE | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-06-24 | — | — | US | disclosed |
| US-7674773-B2 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-03-09 | — | — | US | disclosed |
| US-7576200-B2 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-08-18 | — | — | US | disclosed |
| US-7488829-B2 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-02-10 | — | — | US | disclosed |
| US-20080281092-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | AVENTIS PHARMA DEUTSCHLAND GMBH | 2008-11-13 | — | — | US | disclosed |
| US-20070208179-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | AVENTIS PHARMA DEUTSCHLAND GMBH | 2007-09-06 | — | — | US | disclosed |
| US-6992067-B2 | Diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-01-31 | — | — | US | disclosed |
| US-20050267038-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | AVENTIS PHARMA DEUTSCHLAND GMBH | 2005-12-01 | — | — | US | disclosed |
| US-20020137689-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080281092-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | QDPR, NDUFB6, NDUFB7 | BBOX1 1164/4885GPR84 3424/4885PPARG 618/4885 |
| US-20020137689-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | QDPR, NDUFB7, NDUFB6 | BBOX1 1051/4885GPR84 3480/4885PPARG 703/4885 |
| US-20050267038-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | QDPR, NDUFB6, NDUFB7 | BBOX1 1164/4885GPR84 3424/4885PPARG 618/4885 |
| US-20100160282-A1 | NOVEL DIPHENYLAZETIDINONES, PROCESS FOR THEIR PREPARATION, MEDICAMENTS COMPRISING THESE COMPOUNDS AND THEIR USE | QDPR, NDUFB6, NDUFB7 | BBOX1 1164/4885GPR84 3424/4885PPARG 618/4885 |
| US-20070208179-A1 | Novel diphenylazetidinones, process for their preparation, medicaments comprising these compounds and their use | QDPR, NDUFB6, NDUFB7 | BBOX1 1164/4885GPR84 3424/4885PPARG 618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.