Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B10 | O60218 | 4/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217412 | 1.00 | AKR1B10 (0.41) | AKR1B10AKR1B1HDAC8LMNASMN1; SMN2 | |
| SCHEMBL2772203 | 0.86 | HDAC8 (0.43) | HDAC8LMNASMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL2772199 | 0.86 | HDAC8 (0.43) | HDAC8LMNASMN1; SMN2HDAC3HDAC4 | |
| SCHEMBL3212785 | 0.84 | CNR1 (0.43) | AKR1B10AKR1B1HDAC8LMNASMN1; SMN2 | |
| SCHEMBL3212794 | 0.84 | CNR1 (0.43) | AKR1B10AKR1B1HDAC8LMNASMN1; SMN2 | |
| SCHEMBL3217432 | 0.80 | PSEN1 (0.48) | — | |
| SCHEMBL3217419 | 0.75 | FAAH (0.38) | LMNASMN1; SMN2MAPTCNR1CNR2 | |
| SCHEMBL2767672 | 0.72 | CNR1 (0.47) | LMNAMAPTCNR1CNR2 | |
| SCHEMBL1769268 | 0.69 | ALDH1A1 (0.41) | LMNASMN1; SMN2APPTDP1 | |
| SCHEMBL2767992 | 0.68 | CNR1 (0.48) | HDAC8LMNASMN1; SMN2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048544-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE-DERIVATIVES FOR TREATING TUBERCULOSIS | GLAXO GROUP LIMITED (GB) | 2010-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048544-A1 | PYRROLO (3, 2, 1-IJ) QUINOLINE-4-ONE-DERIVATIVES FOR TREATING TUBERCULOSIS | NQO2, MT-ND1, SDHB | AKR1B10 1538/4885AKR1B1 792/4885HDAC8 2890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.