Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3224891 | 0.95 | HDAC1 (0.35) | HDAC1KDM4EPOLBPKMLRRK2 | |
| SCHEMBL3011716 | 0.88 | LCK (0.41) | HDAC1PKMS1PR3LCKBRAF | |
| SCHEMBL3217239 | 0.86 | KDM4E (0.35) | HDAC1KDM4EPOLBS1PR3LCK | |
| SCHEMBL3213825 | 0.85 | LMNA (0.42) | POLBALDH1A1HPGDBRAF | |
| SCHEMBL3224628 | 0.85 | S1PR3 (0.40) | KDM4EPOLBS1PR3S1PR1 | |
| SCHEMBL3226663 | 0.85 | ALDH1A1 (0.42) | HDAC1KDM4EALDH1A1HPGDTP53 | |
| SCHEMBL3208889 | 0.83 | KDM4E (0.35) | KDM4EPOLBLRRK2S1PR3RXFP1 | |
| SCHEMBL3224938 | 0.83 | HDAC1 (0.36) | HDAC1PKMS1PR3LCKBRAF | |
| SCHEMBL3701195 | 0.83 | LCK (0.39) | HDAC1PKMS1PR3LCKBRAF | |
| SCHEMBL3715668 | 0.81 | PKM (0.41) | HDAC1KDM4EPOLBPKMS1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120556-B1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2016-03-09 | — | — | EP | disclosed |
| US-8389766-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2013-03-05 | — | — | US | disclosed |
| US-8247594-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2012-08-21 | — | — | US | disclosed |
| US-20100130601-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-05-27 | — | — | US | disclosed |
| US-20100056639-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-03-04 | — | — | US | disclosed |
| EP-2120556-A1 | INSECTICIDAL COMPOUNDS | Syngeta Participations AG (CH) | 2009-11-25 | — | — | EP | disclosed |
| EP-2114161-A1 | INSECTICIDAL COMPOUNDS | Syngeta Participations AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008107091-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008074427-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130601-A1 | INSECTICIDAL COMPOUNDS | ACHE, NIT2, CHRM1 | HDAC1 353/4885KDM4E 3298/4885POLB 4682/4885 |
| US-20100056639-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, NIT2 | HDAC1 234/4885KDM4E 2732/4885POLB 4533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.