Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 7/20 | 0.41 |
| ▸ | CMA1 | P23946 | 6/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 3/20 | 0.41 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322298 | 0.88 | F2 (0.43) | CTSGCMA1PRSS1CTRB1F10 | |
| SCHEMBL10056562 | 0.86 | CA1 (0.49) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL2167674 | 0.84 | TMPRSS11D (0.53) | CTSBITGB3ITGA2BPRSS1F10 | |
| SCHEMBL16821242 | 0.78 | ITGB3 (0.56) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL30309011 | 0.75 | ITGB3 (0.65) | ITGB3ITGA2BHDAC3HDAC4HDAC1 | |
| SCHEMBL8347771 | 0.74 | TMPRSS11D (0.58) | F10PLGF11KLKB1F2 | |
| SCHEMBL635785 | 0.73 | TMPRSS11D (0.53) | PRSS1F10PLGF11KLKB1 | |
| SCHEMBL15308907 | 0.73 | F2 (0.51) | F10PLGKLKB1F2 | |
| SCHEMBL3752985 | 0.73 | TMPRSS11D (0.51) | ITGB3ITGA2BPRSS1F10PLG | |
| Hydrochloric Acid SCHEMBL30703151 | 0.70 | ITGB3 (0.54) | ITGB3ITGA2BHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921319-B2 | Serine protease inhibitors | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-2590945-B1 | SERINE PROTEASE INHIBITORS | MEDICINES CO LEIPZIG GMBH (DE) | 2014-04-30 | — | — | EP | disclosed |
| US-20130267467-A1 | SERINE PROTEASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-10-10 | — | — | US | disclosed |
| EP-2590945-A2 | SERINE PROTEASE INHIBITORS | The Medicines Company (Leipzig) GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004678-A2 | SERINE PROTEASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267467-A1 | SERINE PROTEASE INHIBITORS | SERPINE1, KLKB1, SERPINC1 | CTSB 217/4885ITGB3 391/4885ITGA2B 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.