Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 1/20 | 0.41 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.41 |
| ▸ | CMA1 | P23946 | 1/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.39 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.39 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.39 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.39 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.39 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL321996 | 0.88 | CTSB (0.46) | F2F10PRSS1CTSGCTRB1 | |
| SCHEMBL15308907 | 0.85 | F2 (0.51) | F2F10CTNNB1FOLH1PSMB8 | |
| SCHEMBL3752985 | 0.83 | TMPRSS11D (0.51) | F2F10PRSS1 | |
| SCHEMBL635785 | 0.73 | TMPRSS11D (0.53) | F2F10PRSS1 | |
| SCHEMBL1509338 | 0.73 | MMP9 (0.59) | FOLH1ADAMTS4CA2CA1GAA | |
| SCHEMBL6670868 | 0.73 | MMP9 (0.59) | FOLH1ADAMTS4CA2CA1GAA | |
| SCHEMBL7355412 | 0.73 | MMP9 (0.59) | FOLH1ADAMTS4CA2CA1GAA | |
| SCHEMBL10056562 | 0.73 | CA1 (0.49) | F2F10PSMB1PSMB8PSMB9 | |
| SCHEMBL8347227 | 0.72 | F2 (0.56) | F2F10 | |
| SCHEMBL2167674 | 0.72 | TMPRSS11D (0.53) | F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921319-B2 | Serine protease inhibitors | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2014-12-30 | — | — | US | disclosed |
| EP-2590945-B1 | SERINE PROTEASE INHIBITORS | MEDICINES CO LEIPZIG GMBH (DE) | 2014-04-30 | — | — | EP | disclosed |
| US-20130267467-A1 | SERINE PROTEASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2013-10-10 | — | — | US | disclosed |
| EP-2590945-A2 | SERINE PROTEASE INHIBITORS | The Medicines Company (Leipzig) GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004678-A2 | SERINE PROTEASE INHIBITORS | THE MEDICINES COMPANY (LEIPZIG) GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130267467-A1 | SERINE PROTEASE INHIBITORS | SERPINE1, KLKB1, SERPINC1 | F2 6/4885F10 47/4885PRSS1 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.