Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.40 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3226880 | 0.81 | PDE4B (0.52) | PDE4BROCK2ROCK1PRKCZCCR4 | |
| SCHEMBL3577896 | 0.79 | MT-CO2 (0.44) | PDE4BTRPV1MT-CO2ALDH1A1MAPT | |
| SCHEMBL4566834 | 0.77 | PDE4B (0.44) | PDE4BROCK2ROCK1PRKCZCCR4 | |
| SCHEMBL4566836 | 0.75 | CYP1A2 (0.51) | PDE4BROCK2ROCK1PRKCZCCR4 | |
| SCHEMBL9686975 | 0.72 | MT-CO2 (0.41) | MT-CO2ALDH1A1KMT2AMEN1HTT | |
| SCHEMBL9596455 | 0.72 | MT-CO2 (0.54) | MT-CO2ALDH1A1MAPTSMN1; SMN2NSD2 | |
| SCHEMBL25175478 | 0.70 | ADRA2A (0.70) | ROCK2ROCK1CCR4LMNATRPV1 | |
| SCHEMBL3583696 | 0.70 | TRPV1 (0.39) | PDE4BTRPV1MT-CO2ALDH1A1KMT2A | |
| SCHEMBL29565328 | 0.69 | MT-CO2 (0.54) | LMNAMT-CO2ALDH1A1MAPTKDM4E | |
| SCHEMBL7352314 | 0.69 | LMNA (0.49) | PDE4BROCK2ROCK1PRKCZCCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2120933-B1 | ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-07-08 | — | — | EP | disclosed |
| US-8293762-B2 | Isoquinolinopyrrolopyridinones active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-10-23 | — | — | US | disclosed |
| US-20100056556-A1 | ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2010-03-04 | — | — | US | disclosed |
| EP-2120933-A1 | ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | Nerviano Medical Sciences S.r.l. (IT) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008104475-A1 | ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2008-09-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056556-A1 | ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS | CDK2, CDK1, CDK3 | PDE4B 1597/4885ROCK2 313/4885ROCK1 192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.