Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3220592 | 1.00 | TRPM8 (0.44) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL9951821 | 0.79 | EPHX1 (0.49) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL1032282 | 0.79 | EPHX1 (0.49) | TRPM8TRPA1EPHX1TRPV1KCNA5 | |
| SCHEMBL112084 | 0.77 | EPHX1 (0.47) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL29018734 | 0.77 | EPHX1 (0.47) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL7214058 | 0.75 | EPHX1 (0.45) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL9950972 | 0.73 | EPHX1 (0.46) | TRPM8TRPA1EPHX1TRPV1KCNA5 | |
| SCHEMBL15282238 | 0.72 | EPHX1 (0.43) | TRPM8TRPA1EPHX1TRPV1KCNA5 | |
| Lactic Acid SCHEMBL31239678 | 0.72 | EPHX1 (0.43) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 | |
| SCHEMBL10028631 | 0.72 | TRPV1 (0.46) | TRPM8TRPA1EPHX1TRPV1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| WO-2014198366-A1 | GLOVE WITH A COOLING EFFECT | CARL FREUDENBERG KG (DE) | 2014-12-18 | — | — | WO | claimed |
| EP-3356356-B1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED (US) | 2021-05-26 | — | — | EP | disclosed |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | disclosed |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX, INC. | 2019-06-13 | — | — | US | disclosed |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | SENOMYX INC (US) | 2018-09-27 | — | — | US | disclosed |
| US-9732071-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2017-08-15 | — | — | US | disclosed |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | FIRMENICH INCORPORATED | 2017-04-06 | — | — | US | disclosed |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | SENOMYX INC (US) | 2017-03-30 | — | — | US | disclosed |
| EP-2884958-B1 | COSMETIC COMPOUNDS HAVING TIME-DELAYED ACTIVE INGREDIENT RELEASE | HENKEL AG & CO KGAA (DE) | 2017-03-29 | — | — | EP | disclosed |
| US-9517195-B2 | Cosmetic compounds having time-delayed active ingredient release | HENKEL AG & CO. KGAA (DE) | 2016-12-13 | — | — | US | disclosed |
| US-20150157552-A1 | COSMETIC COMPOUNDS HAVING TIME-DELAYED ACTIVE INGREDIENT RELEASE | HENKEL AG & CO. KGAA (DE) | 2015-06-11 | — | — | US | disclosed |
| EP-2318356-B1 | SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | PROCTER & GAMBLE (US) | 2015-03-11 | — | — | EP | disclosed |
| WO-2014198366-A1 | GLOVE WITH A COOLING EFFECT | CARL FREUDENBERG KG (DE) | 2014-12-18 | — | — | WO | disclosed |
| US-20140186272-A1 | SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 2014-07-03 | — | — | US | disclosed |
| US-8754259-B2 | Synthesis of cyclohexane derivatives useful as sensates in consumer products | THE PROCTER & GAMBLE COMPANY (US) | 2014-06-17 | — | — | US | disclosed |
| US-20130216486-A1 | SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | THE PROCTER & GAMBLE COMPANY (US) | 2013-08-22 | — | — | US | disclosed |
| US-8426643-B2 | Synthesis of cyclohexane derivatives useful as sensates in consumer products | THE PROCTER & GAMBLE COMPANY (US) | 2013-04-23 | — | — | US | disclosed |
| US-20100076080-A1 | Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products | THE PROCTER & GAMBLE COMPANY | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140186272-A1 | SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | NISCH, TRPM4, TRPM8 | TRPM8 3/4885TRPA1 10/4885EPHX1 528/4885 |
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | TRPM8 1/4885TRPA1 8/4885EPHX1 4010/4885 |
| US-20190177308-A9 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TRPA1 8/4885EPHX1 3982/4885 |
| US-20180273517-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TRPA1 8/4885EPHX1 3982/4885 |
| US-20170087199-A1 | COMPOSITIONS FOR DELIVERING A COOLING SENSATION | TRPA1, PDE6G, PDE6D | TRPM8 97/4885TRPA1 1/4885EPHX1 3152/4885 |
| US-20100076080-A1 | Synthesis of Cyclohexane Derivatives Useful as Sensates in Consumer Products | NISCH, TRPM4, TRPM8 | TRPM8 3/4885TRPA1 10/4885EPHX1 528/4885 |
| US-20170096418-A1 | COMPOUNDS USEFUL AS MODULATORS OF TRPM8 | TRPM8, TRPM6, TRPM4 | TRPM8 1/4885TRPA1 8/4885EPHX1 3982/4885 |
| US-20130216486-A1 | SYNTHESIS OF CYCLOHEXANE DERIVATIVES USEFUL AS SENSATES IN CONSUMER PRODUCTS | NISCH, TRPM4, TRPM8 | TRPM8 3/4885TRPA1 10/4885EPHX1 528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.