Flupyrsulfuron

Flupyrsulfuron

SCHEMBL3220772

COc1cc(OC)nc(NC(=O)NS(=O)(=O)c2nc(C(F)(F)F)ccc2C(=O)O)n1.COc1ccccc1C(=O)NS(=O)(=O)c1ccc(C(=O)NC2CC2)cc1

nearest known ligand 0.47

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.47
KDM4E B2RXH2 1/20 0.42
MAPK1 P28482 1/20 0.42
AVPR2 P30518 1/20 0.38
GPR27 Q9NS67 1/20 0.38
THRB P10828 1/20 0.37
PPARG P37231 3/20 0.37
EPHX2 P34913 2/20 0.37
CYSLTR1 Q9Y271 2/20 0.37
KCNA3 P22001 1/20 0.36
CDK1 P06493 1/20 0.36
PTK2 Q05397 3/20 0.36
MAPT P10636 2/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.35
ABCC3 O15438 1/20 0.35
ABCC4 O15439 1/20 0.35
ABCC9 O60706 1/20 0.35
ABCB11 O95342 1/20 0.35
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flazasulfuron SCHEMBL3221138 0.87 GAA (0.47) GAAKDM4EMAPK1THRBPTK2
SCHEMBL3226253 0.84 GAA (0.46) GAATHRBPPARGEPHX2CYSLTR1
SCHEMBL3262147 0.84 GAA (0.49) GAAKDM4EMAPK1THRBPPARG
SCHEMBL3218635 0.84 GAA (0.45) GAATHRBPPARGEPHX2CYSLTR1
Nicosulfuron SCHEMBL3224964 0.84 GAA (0.46) GAATHRBPPARGKCNA3CDK1
SCHEMBL3225612 0.84 GAA (0.46) GAATHRBPPARGEPHX2CYSLTR1
Rimsulfuron SCHEMBL3229754 0.82 GAA (0.46) GAATHRBPPARGEPHX2CYSLTR1
SCHEMBL3228011 0.82 GAA (0.43) GAATHRBPPARGEPHX2CYSLTR1
Flupyrsulfuron SCHEMBL115535 0.81 GAA (0.61) GAAKDM4EMAPK1CDK1MAPT
Halosulfuron SCHEMBL3228102 0.81 GAA (0.44) GAATHRBPPARGEPHX2CYSLTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100234227-A1 MICROEMULSION CONCENTRATES BAYER CROPSCIENCE AG (DE) 2010-09-16 US disclosed
US-20100048516-A1 PENETRATION ENHANCER FOR FUNGICIDES BAYER CROPSCIENCE AG (DE) 2010-02-25 US disclosed
US-20080176746-A1 avoids antagonistically reduced activity or overdosage otherwise requiring split applications; by employing an oil suspension concentrate BAYER CROPSCIENCE AG (DE) 2008-07-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100048516-A1 PENETRATION ENHANCER FOR FUNGICIDES DDT, DCPS, TYMP GAA 430/4885KDM4E 869/4885MAPK1 2200/4885
US-20080176746-A1 avoids antagonistically reduced activity or overdosage otherwise requiring split applications; by employing an oil suspension concentrate LIPA, MGLL, ABHD6 GAA 305/4885KDM4E 3886/4885MAPK1 4275/4885
US-20100234227-A1 MICROEMULSION CONCENTRATES ADH1C, MGLL, ADH1A GAA 1835/4885KDM4E 3160/4885MAPK1 3638/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.