Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | MLYCD | O95822 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.35 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13456091 | 0.87 | RXFP1 (0.43) | RXFP1MLYCDPOLBALDH1A1PKM | |
| SCHEMBL3212633 | 0.79 | MLYCD (0.49) | RXFP1MLYCDALDH1A1PKMMAPT | |
| SCHEMBL29409944 | 0.79 | RXFP1 (0.54) | RXFP1MLYCDKMT2AMEN1NR1H4 | |
| SCHEMBL1275272 | 0.79 | MLYCD (0.45) | RXFP1MLYCDPOLBALDH1A1PKM | |
| SCHEMBL3210438 | 0.79 | MAPT (0.49) | POLBALDH1A1PKMMAPK14MAPT | |
| SCHEMBL3224751 | 0.77 | PKM (0.38) | ALDH1A1PKMMAPK14LMNAKMT2A | |
| SCHEMBL3227043 | 0.76 | MLYCD (0.48) | RXFP1MLYCDPOLBALDH1A1PKM | |
| SCHEMBL13424932 | 0.75 | HDAC1 (0.36) | RXFP1ALDH1A1PKMMAPK14LMNA | |
| SCHEMBL3211594 | 0.75 | HCAR3 (0.52) | POLBALDH1A1PKMMAPTLMNA | |
| SCHEMBL289051 | 0.75 | RXFP1 (0.39) | RXFP1MLYCDKMT2AMEN1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140336137-A1 | NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF | CARDIOXYL PHARMACEUTICALS, INC. | 2014-11-13 | — | — | US | disclosed |
| US-20130184343-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130184343-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2013-07-18 | — | — | US | disclosed |
| WO-2013092942-A1 | USE OF AMINOBENZAMIDE DERIVATIVES FOR CONTROLLING ANIMAL PARASITES | SYNGENTA PARTICIPATIONS AG (CH) | 2013-06-27 | — | — | WO | disclosed |
| US-8420855-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420855-B2 | Insecticidal compounds | SYNGENTA CROP PROTECTION LLC (US) | 2013-04-16 | — | — | US | disclosed |
| US-20100048715-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| US-20100048715-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION, INC. (US) | 2010-02-25 | — | — | US | disclosed |
| WO-2008000438-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2008-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140336137-A1 | NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF | NOXO1, TNNI3, HAO2 | RXFP1 1804/4885MLYCD 813/4885POLB 2534/4885 |
| US-20100048715-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, CHRM2 | RXFP1 1992/4885MLYCD 3539/4885POLB 4520/4885 |
| US-20130184343-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, CHRM2 | RXFP1 2047/4885MLYCD 3515/4885POLB 4511/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.