Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705763 | 0.82 | OPRM1 (0.46) | ALDH1A1POLBTSHRGAASMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL2314046 | 0.79 | DPP4 (0.47) | KCNH2 | |
| SCHEMBL2315195 | 0.77 | UBE2M (0.37) | HTTMEN1KMT2AL3MBTL1 | |
| SCHEMBL16581996 | 0.76 | MC4R (0.50) | ALDH1A1KDM4ETDP1SMN1; SMN2CYP2D6 | |
| SCHEMBL12432020 | 0.74 | MCHR1 (0.38) | NPSR1KDM4ELMNACYP2D6CHRM4 | |
| SCHEMBL2312316 | 0.72 | EPHX1 (0.49) | ALDH1A1POLBTSHRGAAKDM4E | |
| SCHEMBL5914401 | 0.70 | EPHX1 (0.48) | ALDH1A1POLBTSHRGAAKDM4E | |
| SCHEMBL27458578 | 0.68 | HTR2A (0.55) | ALDH1A1KDM4ELMNAHTTMAPT | |
| SCHEMBL23928246 | 0.68 | KDM4E (0.50) | ALDH1A1KDM4ELMNAHTT | |
| SCHEMBL23928225 | 0.68 | ALDH1A1 (0.54) | ALDH1A1TSHRNPSR1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1876179-B1 | Thienopyrimidone compounds | TAKEDA PHARMACEUTICAL (JP) | 2015-03-25 | — | — | EP | disclosed |
| US-20100069362-A1 | Thienopyrimidone compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
| EP-1876179-A1 | THIENOPYRIMIDONE COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2008-01-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069362-A1 | Thienopyrimidone compound | MC1R, MC2R, MC5R | ALDH1A1 831/4885POLB 4181/4885TSHR 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.