Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 6/20 | 0.41 |
| ▸ | CES2 | O00748 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14017948 | 0.83 | — | — | |
| SCHEMBL725383 | 0.77 | CES2 (0.39) | CES1CES2ALDH1A1PRKCAAKR1B1 | |
| SCHEMBL11194433 | 0.77 | CES2 (0.46) | CES1CES2ALDH1A1PRKCAAKR1B1 | |
| SCHEMBL31347976 | 0.75 | CES2 (0.48) | CES1CES2ALDH1A1PRKCATHRA | |
| SCHEMBL31347986 | 0.75 | CES2 (0.48) | CES1CES2ALDH1A1PRKCATHRA | |
| SCHEMBL11122445 | 0.75 | CES2 (0.48) | CES1CES2ALDH1A1PRKCATHRA | |
| SCHEMBL2356106 | 0.75 | CES2 (0.48) | CES1CES2ALDH1A1PRKCATHRA | |
| SCHEMBL27488898 | 0.73 | CES1 (0.36) | CES1CES2LMNAALDH1A1TP53 | |
| SCHEMBL6142686 | 0.71 | SMN1; SMN2 (0.47) | LMNAALDH1A1TP53 | |
| SCHEMBL6142683 | 0.71 | SMN1; SMN2 (0.47) | LMNAALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9533974-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | MICHIGAN DIAGNOSTICS, LLC (US) | 2017-01-03 | — | — | US | disclosed |
| US-20150031889-A1 | ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | GIRI BRIJ PAL (US) | 2015-01-29 | — | — | US | disclosed |
| US-8932881-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | GIRI BRIJ PAL (US) | 2015-01-13 | — | — | US | disclosed |
| US-8822233-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | GIRI BRIJ PAL (US) | 2014-09-02 | — | — | US | disclosed |
| US-20140121362-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | MICHIGAN DIAGNOSTICS, LLC (US) | 2014-05-01 | — | — | US | disclosed |
| US-20140088297-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | MICHIGAN DIAGNOSTICS, LLC (US) | 2014-03-27 | — | — | US | disclosed |
| US-20140073771-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | MICHIGAN DIAGNOSTICS, LLC (US) | 2014-03-13 | — | — | US | disclosed |
| US-8546150-B2 | Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates | Michigan Diagnostics, L.L.C. (US) | 2013-10-01 | — | — | US | disclosed |
| US-20100317122-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | GIRI BRIJ PAL | 2010-12-16 | — | — | US | disclosed |
| US-20100317031-A1 | ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | GIRI BRIJ PAL | 2010-12-16 | — | — | US | disclosed |
| EP-1112274-B1 | CHEMILUMINESCENT 1,2-DIOXETANES | GIRI BRIJ P (US) | 2009-12-09 | — | — | EP | disclosed |
| EP-2048140-A1 | Deuterated chemiluminescent 1,2-dioxetanes | Giri, Brij P. (US) | 2009-04-15 | — | — | EP | disclosed |
| US-7422908-B2 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P | 2008-09-09 | — | — | US | disclosed |
| US-7416898-B2 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P | 2008-08-26 | — | — | US | disclosed |
| US-20070225498-A1 | water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. | MICHIGAN DIAGNOSTICS, LLC | 2007-09-27 | — | — | US | disclosed |
| US-6767716-B2 | THE 1,2-DIOXETANE; A POLYMERIC ENHANCER WHICH IS EITHER AN AMMONIUM OR PHOSPHONIUM SALT OF A POLYVINYLBENZYL CHLORIDE AND AN AQUEOUS ENZYME DILUENT OR STABILIZER; DETECTION OF PHOSPHATASE, BETA-GALACTOSIDASE, AND CHOLINESTERASE | GIRI BRIJ P (US) | 2004-07-27 | — | — | US | disclosed |
| US-20040077018-A1 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P (US) | 2004-04-22 | — | — | US | disclosed |
| US-20030213940-A1 | Chemiluminescent 1,2-dioxetanes | GIRI BRIJ P (US) | 2003-11-20 | — | — | US | disclosed |
| US-6461876-B1 | STABLE SPIROFUSED RINGS; DECOMPOSING TO GENERATE LIGHT AND CARBONYL GROUP; HIGH ENERGY; MEDICINE | TOBEN, HOWARD R. | 2002-10-08 | — | — | US | disclosed |
| US-20020013250-A1 | Single molecule detection of alkaline phosphatase enzyme using enhanced chemiluminescence from 1,2-dioxetanes and water-soluble, water-insoluble or partially-water soluble polymers | GIRI BRIJ P (US) | 2002-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077018-A1 | Chemiluminescent 1,2-dioxetanes | CYP19A1, CYP1A1, CYP2F1 | CES1 133/4885CES2 513/4885LMNA 2716/4885 |
| US-20140088297-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | CES1 90/4885CES2 43/4885LMNA 2129/4885 |
| US-20140121362-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | CES1 90/4885CES2 43/4885LMNA 2129/4885 |
| US-20150031889-A1 | ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | CES1 77/4885CES2 43/4885LMNA 1938/4885 |
| US-20070225498-A1 | water-soluble, stable in aqueous buffers, for use in biological assaying include acridane-based compounds and (1,2)-dioxetanes; used in the detection of antibodies or antigen in biological fluids and for compounds, particularly toxins and contaminants in the environment and food. | BTD, DDT, LPO | CES1 196/4885CES2 159/4885LMNA 2310/4885 |
| US-20100317031-A1 | ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, MPO | CES1 69/4885CES2 43/4885LMNA 1953/4885 |
| US-20100317122-A1 | NEW ULTRA-SENSITIVE CHEMILUMINESCENT SUBSTRATES FOR ENZYMES AND THEIR CONJUGATES | DUOX1, XDH, LPO | CES1 112/4885CES2 45/4885LMNA 2175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.