Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ASAH1 | Q13510 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30980576 | 0.88 | LMNA (0.64) | SMN1; SMN2ASAH1HTTLMNAHRH4 | |
| SCHEMBL590652 | 0.82 | RAB9A (0.52) | SMN1; SMN2 | |
| SCHEMBL5859633 | 0.80 | NAMPT (0.53) | SMN1; SMN2ASAH1 | |
| SCHEMBL15570675 | 0.80 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNACYP19A1 | |
| SCHEMBL23455649 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2ASAH1CYP19A1 | |
| SCHEMBL5696270 | 0.79 | NPC1 (0.49) | HRH4CYP19A1CYP11B1CYP11B2FAAH | |
| SCHEMBL31078952 | 0.78 | SMN1; SMN2 (0.42) | SMN1; SMN2HTTLMNAHRH4CYP19A1 | |
| SCHEMBL30980602 | 0.77 | LMNA (0.48) | SMN1; SMN2HTTLMNAHRH4 | |
| SCHEMBL30980778 | 0.76 | HTT (0.44) | SMN1; SMN2HTTLMNAHRH4CYP19A1 | |
| SCHEMBL12031906 | 0.76 | L3MBTL1 (0.33) | SMN1; SMN2HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015588-A1 | BENZYL-SUBSTITUTED TETRACYCLIC HETEROCYCLIC COMPOUNDS | NYCOMED GMBH (DE) | 2010-02-11 | — | — | WO | disclosed |