Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Zamifenacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Zamifenacin SCHEMBL8938193 | 1.00 | KDM4E (0.45) | KDM4EMEN1KMT2AMAPK1MCHR1 | |
| Zamifenacin SCHEMBL1933745 | 0.93 | ADRA1D (0.46) | KDM4EMEN1KMT2AMAPK1MCHR1 | |
| Zamifenacin SCHEMBL311829 | 0.93 | ADRA1D (0.46) | KDM4EMEN1KMT2AMAPK1MCHR1 | |
| Zamifenacin SCHEMBL4603503 | 0.92 | ADRA1D (0.46) | KDM4EMEN1KMT2AMAPK1MCHR1 | |
| Zamifenacin SCHEMBL13957195 | 0.85 | SLC6A2 (0.41) | MAPK1MCHR1OPRM1ADRA1DADRA1A | |
| Zamifenacin SCHEMBL13957310 | 0.85 | SLC6A2 (0.41) | MAPK1MCHR1OPRM1ADRA1DADRA1A | |
| Zamifenacin SCHEMBL13957205 | 0.84 | NOS2 (0.42) | MEN1KMT2AMAPK1MCHR1OPRM1 | |
| Fumaric Acid SCHEMBL8938229 | 0.84 | SLC6A4 (0.44) | KMT2AMAPK1OPRM1OPRK1ADRA1A | |
| Zamifenacin SCHEMBL13957196 | 0.83 | ADRA1D (0.45) | KDM4EMEN1KMT2AMAPK1MCHR1 | |
| SCHEMBL8938462 | 0.83 | KCNH2 (0.44) | KDM4EALDH1A1LMNAGAAADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190336490-A1 | COMPOSITIONS AND METHODS FOR INCREASING REMYELINATION | Frequency Therapeutics, Inc. | 2019-11-07 | — | — | US | disclosed |
| WO-2016021599-A1 | COMPOSITION FOR ENHANCING INDUCTION OF HUMORAL IMMUNITY, AND VACCINE PHARMACEUTICAL COMPOSITION | 日東電工株式会社 | 2016-02-11 | — | — | WO | disclosed |
| WO-2010015037-A1 | THERAPEUTIC METHODS AND COMPOSITIONS | HOWARD FLOREY INSTITUTE (AU) | 2010-02-11 | — | — | WO | disclosed |