Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 4/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3232743 | 0.91 | HTR2C (0.41) | HTR2CSLC6A4HTR2BS1PR1S1PR5 | |
| SCHEMBL3219686 | 0.82 | LMNA (0.40) | KDM4EALDH1A1LMNAGAAHTT | |
| SCHEMBL30821972 | 0.78 | SLC6A4 (0.56) | HTR2CSLC6A4HTR2BMRGPRX4LRRK2 | |
| SCHEMBL1332170 | 0.78 | SLC6A4 (0.56) | HTR2CSLC6A4HTR2BMRGPRX4LRRK2 | |
| SCHEMBL10268708 | 0.76 | MAOB (0.43) | S1PR1S1PR5KDM4EALDH1A1LMNA | |
| SCHEMBL2801046 | 0.75 | CCNT1 (0.44) | SLC6A4KDM4ELMNAKMT2ACD274 | |
| Benzyl Bromide SCHEMBL5984626 | 0.74 | SLC6A4 (0.52) | HTR2CSLC6A4HTR2BMRGPRX4LRRK2 | |
| SCHEMBL13845126 | 0.73 | OPRM1 (0.44) | HTR2CHTR2BKDM4EALDH1A1LMNA | |
| SCHEMBL21061062 | 0.73 | KDM4E (0.38) | SLC6A4S1PR1S1PR5S1PR4KDM4E | |
| SCHEMBL325593 | 0.72 | HTR1A (0.49) | HTR2CSLC6A4HTR2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575167-B2 | Spiro compounds having stearoyl-CoA desaturase action | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-11-05 | — | — | US | disclosed |
| US-20100069351-A1 | SPIRO COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069351-A1 | SPIRO COMPOUND AND USE THEREOF | SCD, SPR, SCD5 | HTR2C 3255/4885SLC6A4 3528/4885HTR2B 1654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.