Sugi Predict

Sugi Predict / Compounds / SCHEMBL3229357

SCHEMBL3229357

SCHEMBL3229357

CC(N)c1cc2ccccc2[nH]1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 1/20 0.55
▸ AOC3 Q16853 2/20 0.50
▸ LOXL2 Q9Y4K0 1/20 0.46
▸ BRD4 O60885 1/20 0.44
▸ KDM4E B2RXH2 6/20 0.44
▸ LMNA P02545 1/20 0.44
▸ TP53 P04637 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ CA2 P00918 1/20 0.43
▸ RAB9A P51151 3/20 0.42
▸ NPC1 O15118 2/20 0.42
▸ FLT3 P36888 1/20 0.41
▸ CYP2A6 P11509 1/20 0.41
▸ MAPT P10636 4/20 0.41
▸ ALDH1A1 P00352 3/20 0.41
▸ DAO P14920 2/20 0.40
▸ HPGD P15428 2/20 0.40
▸ SRD5A2 P31213 1/20 0.40
▸ HSD17B10 Q99714 1/20 0.40
▸ DDO Q99489 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4985929 0.83 ALOX5 (0.54) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL336690 0.83 ALOX5 (0.54) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL30733359 0.83 ALOX5 (0.54) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL22529424 0.81 ALOX5 (0.60) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL23468379 0.80 ALOX5 (0.51) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL19981811 0.80 ALOX5 (0.51) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL3663172 0.80 ALOX5 (0.55) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL31299796 0.80 ALOX5 (0.55) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL5049788 0.80 AOC3 (0.50) ALOX5AOC3LOXL2BRD4KDM4E
SCHEMBL1706542 0.80 ALOX5 (0.51) ALOX5AOC3LOXL2BRD4KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4002611-A Preparation of benzodiazepines SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-01-11 — — US claimed
JP-7149723-A — — None — — JP disclosed
US-11845742-B2 Therapeutic compounds and methods to treat infection RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-12-19 — — US disclosed
US-20200325124-A1 THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2020-10-15 — — US disclosed
US-20200325124-A1 THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY 2020-10-15 — — US disclosed
US-10010554-B2 Fused pyrimidines as inhibitors of P97 complex CLEAVE BIOSCIENCES, INC. (US) 2018-07-03 — — US disclosed
US-10010554-B2 Fused pyrimidines as inhibitors of P97 complex CLEAVE BIOSCIENCES, INC. (US) 2018-07-03 — — US disclosed
WO-2018048930-A1 LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF PHARMAKEA, INC. (US) 2018-03-15 — — WO disclosed
EP-2875018-B1 FUSED PYRIMIDINES AS INHIBITORS OF p97 COMPLEX CLEAVE BIOSCIENCES INC (US) 2018-02-14 — — EP disclosed
US-20170258795-A1 FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX CLEAVE THERAPEUTICS, INC. 2017-09-14 — — US disclosed
US-5430038-A Antipsychotic agents HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1995-07-04 — — US disclosed
JP-H07149723-A 1-AMINOETHYLINDOLE DERIVATIVE F HOFFMANN LA ROCHE AG 1995-06-13 — — JP disclosed
EP-0655440-A2 1-Aminoethylindoles F. HOFFMANN-LA ROCHE AG (CH) 1995-05-31 — — EP disclosed
US-5292883-A Antipsychotics HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1994-03-08 — — US disclosed
US-5229517-A Intermediates for antipsychotic agents HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1993-07-20 — — US disclosed
EP-0481254-A2 2-(4-Piperidinyl)-1H-pyrido[4,3-b]indol-1 ones and related compounds, intermediates and a process for their preparation HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-04-22 — — EP disclosed
US-5102889-A For treating psychosis HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1992-04-07 — — US disclosed
US-4076537-A Light-sensitive materials containing organo tellurium or selenium compounds and sensitizers FUJI PHOTO FILM CO., LTD. (JA) 1978-02-28 — — US disclosed
US-4002611-A Preparation of benzodiazepines SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-01-11 — — US disclosed
US-4002611-A Preparation of benzodiazepines SUMITOMO CHEMICAL COMPANY, LIMITED (JA) 1977-01-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170258795-A1 FUSED PYRIMIDINES AS INHIBITORS OF P97 COMPLEX PSMG3, PSME1, PSMB1 ALOX5 4152/4885AOC3 1907/4885LOXL2 3527/4885
US-20200325124-A1 THERAPEUTIC COMPOUNDS AND METHODS TO TREAT INFECTION ABCB11, SLC47A1, SLC47A2 ALOX5 2482/4885AOC3 2807/4885LOXL2 3495/4885
US-10010554-B2 Fused pyrimidines as inhibitors of P97 complex PSMG3, PSME1, PSMB1 ALOX5 4152/4885AOC3 1907/4885LOXL2 3527/4885
US-11845742-B2 Therapeutic compounds and methods to treat infection ABCB11, SLC47A1, SLC47A2 ALOX5 2482/4885AOC3 2807/4885LOXL2 3495/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.