Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236799 | 0.87 | LMNA (0.44) | HPGDALDH1A1KDM4ENPSR1GPR55 | |
| SCHEMBL1064934 | 0.80 | HDAC3 (0.42) | HDAC1LMNAHDAC3HDAC4HDAC7 | |
| SCHEMBL3233951 | 0.77 | HDAC3 (0.42) | HDAC1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL3262923 | 0.76 | GRM1 (0.44) | ALDH1A1MEN1KMT2AHDAC1LMNA | |
| SCHEMBL5380991 | 0.75 | ALOX15 (0.45) | HPGDALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL16369620 | 0.75 | ALDH1A1 (0.40) | ALDH1A1NPSR1MEN1KMT2AHDAC1 | |
| SCHEMBL3242812 | 0.75 | ALDH1A1 (0.40) | ALDH1A1NPSR1MEN1KMT2AHDAC1 | |
| SCHEMBL5351345 | 0.73 | ALOX15 (0.49) | ALDH1A1KDM4EMEN1KMT2AHDAC1 | |
| SCHEMBL3233725 | 0.73 | ALDH1A1 (0.39) | ALDH1A1HDAC1LMNATP53HDAC3 | |
| SCHEMBL3236792 | 0.72 | HDAC1 (0.42) | NPSR1HDAC1TP53HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |