Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | EEF2K | O00418 | 1/20 | 0.36 |
| ▸ | MARK3 | P27448 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.36 |
| ▸ | NEK4 | P51957 | 1/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.36 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.36 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.36 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4261000 | 0.86 | MAPT (0.56) | MEN1KMT2ARCE1MAPTNPSR1 | |
| SCHEMBL7271163 | 0.83 | CACNA1C (0.50) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL3049870 | 0.79 | KMT2A (0.49) | MEN1KMT2ARCE1MAPTNPSR1 | |
| SCHEMBL7272604 | 0.77 | KMT2A (0.47) | MEN1KMT2ARCE1MAPTNPSR1 | |
| SCHEMBL7282347 | 0.73 | MTOR (0.40) | KDM4EUBE2MDCUN1D1 | |
| SCHEMBL7282581 | 0.73 | ALDH1A1 (0.38) | MEN1KMT2AMAPTNPSR1KDM4E | |
| SCHEMBL7282056 | 0.72 | CACNA1C (0.67) | MEN1KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL9401663 | 0.72 | KDM4E (0.58) | MEN1KMT2ARCE1MAPTNPSR1 | |
| SCHEMBL7278639 | 0.71 | TSHR (0.52) | MEN1KMT2AMAPTNPSR1KDM4E | |
| SCHEMBL9506294 | 0.71 | GAA (0.33) | KMT2AMAPTALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002483-A1 | OPTIONALLY CONDENSED DIHYDRO PYRIDINE, DIHYDROPYRIMIDINE AND DIHYDRO PYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2010-01-07 | — | — | WO | disclosed |