Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.41 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.41 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.41 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282419 | 0.85 | ADORA3 (0.62) | KMT2AMEN1MAPTCACNA1CKDM4E | |
| SCHEMBL7271096 | 0.78 | CA1 (0.46) | KMT2AMEN1MAPTNPSR1CACNA1C | |
| SCHEMBL4261000 | 0.78 | MAPT (0.56) | KMT2AMEN1RCE1MAPTNPSR1 | |
| SCHEMBL3059360 | 0.77 | KDM4E (0.64) | KMT2AMEN1RCE1MAPTNPSR1 | |
| SCHEMBL7280324 | 0.77 | ALDH1A1 (0.48) | KMT2AMEN1MAPTNPSR1CACNA1C | |
| SCHEMBL7278542 | 0.77 | MEN1 (0.59) | KMT2AMEN1MAPTCACNA1CCYP1A2 | |
| SCHEMBL7282581 | 0.77 | ALDH1A1 (0.38) | KMT2AMEN1MAPTNPSR1CACNA1C | |
| SCHEMBL3235004 | 0.77 | MEN1 (0.40) | KMT2AMEN1RCE1MAPTNPSR1 | |
| SCHEMBL7280765 | 0.76 | CACNA1D (0.54) | KMT2AMEN1MAPTCACNA1CKDM4E | |
| SCHEMBL7271466 | 0.76 | CACNA1C (0.54) | KMT2AMEN1MAPTCACNA1CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |