Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7282275 | 0.88 | CA1 (0.49) | MAPTNPSR1KDM4EALDH1A1CACNA1C | |
| SCHEMBL3235004 | 0.86 | MEN1 (0.40) | MAPTNPSR1PKMKDM4EALDH1A1 | |
| SCHEMBL7278639 | 0.86 | TSHR (0.52) | MAPTNPSR1KDM4EALDH1A1CACNA1C | |
| SCHEMBL7282331 | 0.84 | ACHE (0.56) | MAPTKDM4EALDH1A1CACNA1CHSD17B10 | |
| SCHEMBL7281990 | 0.83 | ADORA3 (0.58) | KDM4EALDH1A1CACNA1CHSD17B10CASP1 | |
| SCHEMBL2996737 | 0.81 | MAPT (0.70) | MAPTNPSR1PKMKDM4EALDH1A1 | |
| SCHEMBL4252894 | 0.80 | MAPT (0.46) | MAPTNPSR1PKMKDM4EALDH1A1 | |
| SCHEMBL3248414 | 0.80 | MAPT (0.57) | MAPTNPSR1PKMKDM4EALDH1A1 | |
| SCHEMBL7272604 | 0.78 | KMT2A (0.47) | MAPTNPSR1KDM4EALDH1A1CACNA1C | |
| SCHEMBL7273090 | 0.78 | ACHE (0.54) | MAPTKDM4EALDH1A1CACNA1CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |