Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28867171 | 0.86 | ADRB2 (0.62) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL1242029 | 0.85 | ALDH1A1 (0.71) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL3236859 | 0.83 | ALDH1A1 (0.55) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL13117142 | 0.75 | ALDH1A1 (0.41) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL10112780 | 0.73 | MEN1 (0.48) | ALDH1A1LMNAMEN1KMT2AL3MBTL1 | |
| SCHEMBL8009796 | 0.72 | LMNA (0.68) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL15063358 | 0.72 | ALDH1A1 (0.73) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL24723410 | 0.72 | MGLL (0.49) | ALDH1A1LMNAMEN1KMT2ATSHR | |
| SCHEMBL1927517 | 0.72 | LTA4H (0.49) | ALDH1A1TSHRL3MBTL1OPRM1KDM4E | |
| SCHEMBL1927983 | 0.72 | LTA4H (0.49) | ALDH1A1TSHRL3MBTL1OPRM1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |
| WO-2010010184-A1 | [1, 2, 4] TRIAZOLO [1, 5-A] PYRIDINES AS JAK INHIBITORS | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |