Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | RARA | P10276 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | RARG | P13631 | 1/20 | 0.41 |
| ▸ | GOT1 | P17174 | 1/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447663 | 0.81 | CNR2 (0.50) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL4748043 | 0.78 | KMT2A (0.43) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL9763566 | 0.78 | KMT2A (0.43) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL11783889 | 0.78 | ALDH1A1 (0.49) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL9763559 | 0.77 | KMT2A (0.42) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL7904172 | 0.77 | KMT2A (0.48) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL6878528 | 0.77 | KMT2A (0.51) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL18043698 | 0.76 | CNR2 (0.48) | KMT2ACNR2PPARGMEN1LMNA | |
| SCHEMBL18043697 | 0.76 | CNR2 (0.48) | KMT2ACNR2MEN1LMNATDP1 | |
| SCHEMBL5613344 | 0.76 | PPARG (0.44) | KMT2ACNR2PPARGMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210869-A1 | New method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | Galderma Research & Development (FR) | 2010-07-28 | — | — | EP | claimed |
| EP-1868980-B1 | NEW METHOD FOR THE PREPARATION OF 6-(3-(1-ADAMANTYL)-4-METHOXPHENYL)-2-NAPHTHOIC ACID | GALDERMA RES & DEV (FR) | 2010-07-28 | — | — | EP | claimed |
| US-7498461-B2 | Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-03 | — | — | US | claimed |
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-04-17 | — | — | US | claimed |
| EP-1868980-A2 | NEW METHOD FOR THE PREPARATION OF 6-(3-(1-ADAMANTYL)-4-METHOXPHENYL)-2-NAPHTHOIC ACID | Galderma Research & Development (FR) | 2007-12-26 | — | — | EP | claimed |
| WO-2006108717-A2 | NEW METHOD FOR THE PREPARATION OF 6-(3-(1-ADAMANTYL)-4-METHOXPHENYL)-2-NAPHTHOIC ACID | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2006-10-19 | — | — | WO | claimed |
| EP-2210869-A1 | New method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | Galderma Research & Development (FR) | 2010-07-28 | — | — | EP | disclosed |
| EP-1868980-B1 | NEW METHOD FOR THE PREPARATION OF 6-(3-(1-ADAMANTYL)-4-METHOXPHENYL)-2-NAPHTHOIC ACID | GALDERMA RES & DEV (FR) | 2010-07-28 | — | — | EP | disclosed |
| US-7498461-B2 | Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-03 | — | — | US | disclosed |
| US-7498461-B2 | Method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2009-03-03 | — | — | US | disclosed |
| WO-2008126104-A2 | NOVEL PROCESS FOR PREPARATION OF ADAPALENE | INDOCO REMEDIES LIMITED (IN) | 2008-10-23 | — | — | WO | disclosed |
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-04-17 | — | — | US | disclosed |
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-04-17 | — | — | US | disclosed |
| US-7345189-B2 | Process for the preparation of adapalene | DIPHARMA S.P.A. (IT) | 2008-03-18 | — | — | US | disclosed |
| EP-1868980-A2 | NEW METHOD FOR THE PREPARATION OF 6-(3-(1-ADAMANTYL)-4-METHOXPHENYL)-2-NAPHTHOIC ACID | Galderma Research & Development (FR) | 2007-12-26 | — | — | EP | disclosed |
| EP-1707555-B1 | A process for the preparation of adapalene | LUNDBECK PHARMACEUTICALS ITALY (IT) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006108717-A2 | NEW METHOD FOR THE PREPARATION OF 6-(3-(1-ADAMANTYL)-4-METHOXPHENYL)-2-NAPHTHOIC ACID | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2006-10-19 | — | — | WO | disclosed |
| US-20060229465-A1 | Process for the preparation of adapalene | LUNDBECK PHARMACEUTICALS ITALY S.P.A. (IT) | 2006-10-12 | — | — | US | disclosed |
| EP-1707555-A1 | A process for the preparation of adapalene | Dipharma S.p.A. (IT) | 2006-10-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080091045-A1 | Novel method for the preparation of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid | CYP2B6, CYP2A6, CYP26B1 | KMT2A 3014/4885CNR2 2456/4885PPARG 1880/4885 |
| US-20060229465-A1 | Process for the preparation of adapalene | NR3C2, NR0B2, NR0B1 | KMT2A 3713/4885CNR2 473/4885PPARG 1979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.