Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.48 |
| ▸ | CNR2 | P34972 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | GOT1 | P17174 | 1/20 | 0.44 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6878528 | 0.89 | KMT2A (0.51) | KMT2AP2RX7CNR2PPARGMEN1 | |
| SCHEMBL9622121 | 0.82 | ALDH1A1 (0.53) | KMT2ACNR2MEN1LMNANR1I2 | |
| SCHEMBL9622135 | 0.79 | RARB (0.61) | KMT2ACNR2MEN1LMNANR1I2 | |
| SCHEMBL6447663 | 0.79 | CNR2 (0.50) | KMT2AP2RX7CNR2PPARGMEN1 | |
| SCHEMBL3235386 | 0.77 | KMT2A (0.44) | KMT2AP2RX7CNR2PPARGMEN1 | |
| SCHEMBL4748043 | 0.76 | KMT2A (0.43) | KMT2AP2RX7CNR2PPARGMEN1 | |
| SCHEMBL9763566 | 0.76 | KMT2A (0.43) | KMT2AP2RX7CNR2PPARGMEN1 | |
| SCHEMBL11783889 | 0.75 | ALDH1A1 (0.49) | KMT2AP2RX7CNR2PPARGMEN1 | |
| SCHEMBL9125797 | 0.75 | KMT2A (0.51) | KMT2AP2RX7CNR2MEN1LMNA | |
| SCHEMBL8839170 | 0.75 | KMT2A (0.57) | KMT2ACNR2MEN1LMNANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6194450-B1 | KERATINIZATION DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 2001-02-27 | — | — | US | disclosed |
| US-5849798-A | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-12-15 | — | — | US | disclosed |
| US-5212203-A | Skin disorders | CENTRE INTERNATIONAL DE RECHERCHES DERMATOGOLOGIQUES (C.I.R.D.) (FR) | 1993-05-18 | — | — | US | disclosed |
| US-4927928-A | SKIN DISORDERS, EYES, ANTITUMOR | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) | 1990-05-22 | — | — | US | disclosed |